Arizona Diamondbacks continue their four-game series in St. Louis, Missouri against the Cardinals on Wednesday.
The Cardinals took the series opener on Monday behind three early scores and six dominant innings from Andre Pallante.
The Diamondbacks responded with a 4-3 victory Tuesday thanks to four ninth-inning runs. In fact, all seven runs in that game were scored in the ninth inning.
Nolan Arenado, the ex-Cardinal, has an RBI in each game for the Diamondbacks, while Alec Burleson has an RBI in each game for the Cardinals.
The Diamondbacks have been better against the run line than they have winning games straight up, entering this game 45-34 against the run line, with the Under on the run total dominating their games by hitting 43 times.
Meanwhile, the Cardinals have been steady in the betting market, entering 45-32 against the run line and 34-39-4 on Over/Unders.
First pitch is at 7:45 PM ET, as 22-year-old Mitch Bratt makes his MLB debut for the Diamondbacks, squaring off against Matthew Liberatore on the mound.
Diamondbacks vs. Cardinals betting picks and predictions
Cardinals ML (-120)
The No. 14 prospect in the Diamondbacks' system makes his MLB debut on the mound. He is a 22-year-old southpaw who commands the zone well, but he does not possess eye-popping velocity or a definitive plus pitch.
He posted a 2.84 ERA over 44.1 Triple-A innings this year, with 42 strikeouts to 12 walks and four home runs allowed.
The Cardinals are just 15th in OPS against lefties and 20th in OPS at home, but they rank 11th in night games.
Jordan Walker and Ivan Herrera are set to feast, as each player owns an OPS north of .930 against left-handed pitching.
Masyn Winn has also been far better against lefties and Nelson Velasquez is a lefty killer, racking up seven hits in 21 at-bats in 2026, including two doubles and two home runs.
Both teams feature bullpens that rank in the bottom 10 in baseball by ERA, but I trust Liberatore far more than an unproven, soft-throwing lefty making his MLB debut.
Furthermore, while the Diamondbacks' offense makes its money against southpaws, they rank 28th in OPS on the road, which caps their ceiling a bit. I do think they score some runs, but the Cardinals should win a shootout.
The Cardinals also just faced a crafty lefty veteran in Eduardo Rodriguez.
While Rodriguez shut them down, getting a second consecutive crack at a pitcher who doesn’t possess as much movement or a refined pitching arsenal, so should allow the Cardinals to do damage early and often.
Over 9 total runs (-110)
The Cardinals send a pitcher to the mound who has had a disappointing start to his 2026 campaign and owns a massive 10.45 ERA in June.
Liberatore entered the season with high expectations to take the next step and lead this rotation, but he has failed to complete five innings in all three of his June starts, sporting a 5.23 ERA and a 1.56 WHIP on the season.
To make matters worse, Liberatore owns a 5.68 ERA across eight night games.
Lefties have hit the southpaw extra hard this year. Concerningly for St. Louis, the Diamondbacks' star left-handed hitter Corbin Carroll also owns reverse splits, creating a 1.123 OPS against lefties.
In a limited sample size against Arizona, Liberatore has surrendered five hits in 14 at-bats, including a double to Ketel Marte.
The Diamondbacks also rank fifth in MLB in OPS against left-handed pitching (.762). Carroll, Marte (.878 OPS), and Ildemaro Vargas (.860 OPS) are the primary reasons for that success.
The first game in this series featured five runs and the second seven - all of which came in the ninth inning. I like that late-inning momentum to carry into this matchup.
Both bullpens are struggling, the Diamondbacks crush lefties and the Cardinals get to face a mid-level prospect making his MLB debut in enemy territory. Give me 11+ runs.
Jordan Walker to hit a home run (+380)
It may not be a juicy value, but Walker is due to go deep and a left-handed pitcher making his MLB debut is the perfect recipe.
Walker has logged six home runs off southpaws in 70 at-bats, and two of his three June home runs have come against lefties.
He has not homered since June 13 and his slugging metrics have been down overall this month. However, he still has 18 home runs (12th in MLB) and 57 RBIs (2nd in MLB) on the season.
Walker remains the Cardinals' best hitter against lefties and the two hits he collected against Rodriguez last night should give him extra confidence to launch one here.
Bratt surrendered a 1.3 HR/9 rate during 2025 and he is quite hittable with his low velocity when he doesn't locate his pitches perfectly. It’s a "safer" prop pick, but give me Walker to go deep.
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Diamondbacks vs. Cardinals odds
Arizona Diamondbacks | +100 ML |
St. Louis Cardinals | -120 ML |
Run Line | ARI Diamondbacks -1.5 |
Total | O/U 9.0 |
Diamondbacks vs. Cardinals player props
Player home run odds
Jordan Walker (STL Cardinals) | +380 |
Corbin Carroll (ARI Diamondbacks) | +425 |
Ketel Marte (ARI Diamondbacks) | +475 |
Alec Burleson (STL Cardinals) | +475 |
Ivan Herrera (STL Cardinals) | +500 |
Nolan Arenado (ARI Diamondbacks) | +525 |
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This article was written by a partner sports writer via Spotlight Sports Group. All odds displayed on this page were correct at the time of writing and are subject to withdrawal or change at any time.
