The 2026 college football seasons continues, with Week 5 featuring six huge games with home underdogs.
The best quarterbacks are back in action this week, including a high profile matchup between Keelon Russell and Kamario Taylor in Alabama vs. Mississippi State.
Julian Sayin and Ohio State will also take on the stout Iowa defense in a Big Ten heavyweight bout. Iowa is undefeated through four games, but will they be able to hand the perennial contenders their second loss of the season?
Check out the best games of the Week 5 college football slate below:
Best Games in College Football: Week 5
Friday, October 2
Penn State @ Northwestern
Kickoff Time: 8:00 PM ET
TV Channel: FOX
Betting Odds:
Spread | Total (O/U) | Money | |
Penn State | -3.0 +100 | O 45.5 -110 | -150 |
Northwestern | +3.0 -120 | U 45.5 -110 | +125 |
Penn State vs. Northwestern Predictions & Best Bets.
Saturday, October 3
Notre Dame @ North Carolina
Kickoff Time: 12:00 PM ET
TV Channel: ESPN, Disney+
Betting Odds:
Spread | Total (O/U) | Money | |
Notre Dame | -21.5 -110 | O 46.5 -115 | -2000 |
North Carolina | +21.5 -110 | U 46.5 -105 | +1000 |
Alabama @ Mississippi State
Kickoff Time: 12:00 PM ET
TV Channel: ABC
Betting Odds:
Spread | Total (O/U) | Money | |
Alabama | -6.0 -110 | O 60.5 -110 | -225 |
Mississippi State | +6.0 -110 | U 60.5 -110 | +185 |
Keelon Russell vs. Kamario Taylor Player Props & Odds.
Ohio State @ Iowa
Kickoff Time: 3:30 PM ET
TV Channel: CBS
Betting Odds:
Spread | Total (O/U) | Money | |
Ohio State | -14.5 -110 | O 45.5 -110 | -600 |
Iowa | +14.5 -110 | U 45.5 -110 | +450 |
Florida @ Missouri
Kickoff Time: 3:30 PM ET
TV Channel: ABC
Betting Odds:
Spread | Total (O/U) | Money | |
Florida | -5.5 -105 | O 57.5 -110 | -220 |
Missouri | +5.5 -115 | U 57.5 -110 | +180 |
Miami @ Clemson
Kickoff Time: 7:30 PM ET
TV Channel: ABC
Betting Odds:
Spread | Total (O/U) | Money | |
Miami | -16.5 -115 | O 47.5 -115 | -850 |
Clemson | +16.5 -105 | U 47.5 -105 | +575 |
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