Bournemouth and Aston Villa will be looking to book their spot in the EFL Cup quarter finals as they face off on Wednesday night.
Despite their struggles in the Premier League to this point, the Cherries have been flawless in cup competitions, winning 4-0 in their EFL Cup round three clash with Lincoln City and earning a maximum nine points from their Europa League matches so far.
Similarly, the Villans had early Premier League issues, despite now winning four of their last five in the division, but beat Coventry 3-1 in round three of this competition and won all three of their UEFA Champions League matches so far.
With both sides juggling their respective European competitions, it is likely that they will make significant changes to their squads for Wednesday's fourth round clash.
With all that in mind, let's take a look at the team news and predicted lineups for both sides.
Bournemouth escaped Old Trafford with no new injury worries ahead of the midweek fixtures, but are likely to rotate given their European excursions this campaign.
Back up keeper Michele Di Gregorio - on loan from Juventus - should start in place of Djordje Petrovic in goal, as is the standard for most Premier League sides.
Julio Soler could be given a run at left back, in place of Adrien Truffert, with Adam Smith retaining his spot at right back for experience.
Antonio Silva could partner Bafode Diakite at the back, allowing James Hill some rest, behind a midfield pivot of Lewis Cook and Ryan Christie.
Marcus Tavernier, who has started the season exceptionally, will likely retain his spot in the side, with David Brooks and Ben Gannon-Doak given the chance for some much needed game time.
Uruguayan striker Alvaro Rodriguez started the Cherries' 4-0 round three win over Lincoln City and should be afforded the same responsibility on Wednesday night.
(4-2-3-1): Michele Di Gregorio; Julio Soler, Bafode Diakite, Antonio Silva, Adam Smith; Lewis Cook, Ryan Christie; Marcus Tavernier, David Brooks, Ben Gannon-Doak; Alvaro Rodriguez.
After a flurry of early season injuries, the Villans have began to regain the majority of their squad back from injury, with long term absentees Matteo Ruggeri, Aaron Wan-Bissaka and Amadou Onana the only notable players unavailable for the trip south.
Marco Bizot is likely to start in goal for the Villans on Wednesday, having started the round three rout of Coventry, giving Zion Suzuki some much deserved rest.
Ian Maatsen and Matty Cash are the only available full backs for the match, meaning they are likely to start in a back four which should see Taylor Harwood-Bellis and Tyrone Mings reform the partnership from the trip to Coventry.
Leon Goretzka could make his first start for the club in this match, alongside Joao Gomes in the double pivot.
Emiliano Buendia and Ibrahim Mbaye should come in as straight swaps for John McGinn and Alysson, with Ross Barkley - who has had a surprisingly strong start to the new season - allowing Johan Manzambi to manage his minutes as he returns from a knock sustained against Newcastle.
The headline inclusion would be that of 17-year-old Brian Madjo, in what would be his first start for the club since scoring in the 2-1 UEFA Super Cup defeat against PSG.
(4-2-3-1): Marco Bizot; Ian Maatsen, Tyrone Mings, Taylor Harwood-Bellis, Matty Cash; Joao Gomes, Leon Goretzka; Emiliano Buendia, Ross Barkley, Ibrahim Mbaye; Brian Madjo.
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