Anderlecht needed less than a minute to open the scoring on last week's Europa League trip to PAOK, who failed to come up with a response in Greece.
Mihajlo Cvetkovic's early strike turned out to be the only goal of the game so PAOK need to overturn a 1-0 deficit in Brussels on Thursday.
The winners of this tie in the third qualifying round will play off against Kairat Almaty or Levski Sofia for a place in the league phase of the Europa League.
PAOK reached the first knockout stage in last season's Europa League, losing to Celta Vigo, but they will drop into the Conference League if they fail to turn the tie around in Belgium.
Anderlecht v PAOK Tips Summary
Best Bet - Anderlecht to win & both teams to score @ 5/1
Alternative Bet - Ali Maamar to score at any time @ 8/1
Bet Builder - Over 2.5 goals, Anderlecht or draw double chance & Mihajlo Cvetkovic to score @ 9/2
Anderlecht v PAOK Prediction
Best Bet - Anderlecht to win & both teams to score @ 5/1
Anderlecht managed only one further shot on target after taking the lead in the first leg of their Europa League qualifying tie against PAOK.
That was out of character for the Belgians, who have beaten Hammarby 3-1 and RAAL La Louviere 2-1 in their first two home fixtures this season.
Both teams have scored in 14 of Anderlecht's last 16 games and eight of their last nine home matches featured over 3.5 goals.
PAOK qualified from the league phase of last season's Europa League but they will have to take risks if they are to overturn a 1-0 deficit in Brussels.
The balance of the tie means backing Anderlecht to win and both teams to score is an appealing bet.
Both teams scored in both legs of Anderlecht's tie against Hammarby and PAOK beat Dynamo Kyiv 5-2 on aggregate in the previous round.
However, the Greeks struggled on their travels last season, both domestically and in Europe, and could come up short in a lively clash with their free-scoring hosts.
Alternative Bet - Ali Maamar to score at any time @ 8/1
Anderlecht left it late to seal a 2-1 home win over 10-man RAAL La Louviere in their Belgian Pro League opener on Sunday.
Adriano Bertaccini scored their winner in the second minute of injury time, giving new manager Vitor Bruno a successful league debut.
Former Porto coach Bruno is clearly keen for his full-backs to get forward and join in attacks.
No player on the pitch had more shots than Anderlecht right-back Ali Maamar's four and the Moroccan youngster also set up Joshua Nga Kana's equaliser.
Maamar claimed another assist in the home win over Hammarby and looks a big price to score his first goal for the club against PAOK this week.
Anderlecht v PAOK Bet Builder Tip
Over 2.5 goals
Anderlecht or draw double chance
Mihajlo Cvetkovic to score
Pays 9/2
Eight of Anderlecht's last nine home fixtures in all competitions produced over 3.5 goals so over 2.5 goals looks a solid Bet Builder selection on Thursday.
Anderlecht or draw double chance is another tempting bet. The Belgians won the away leg 1-0 and made a successful start to their domestic campaign last weekend.
Mihajlo Cvetkovic scored the only goal of the first leg in Greece and the young striker should kick on after claiming 10 goals in just 19 league starts for Anderlecht in 2025/26.
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Key Match Stats
Both teams scored in 14 of Anderlecht's last 16 matches in all competitions
Anderlecht's four fixtures this season featured only three first-half goals
There were over 3.5 goals in seven of Anderlecht's last 11 games
Five of PAOK's last nine matches in 2025/26 ended in draws
PAOK have won only two of their last 11 away games in all competitions
Giannis Konstantelias scored three of PAOK's five goals against Dynamo Kyiv in the previous round
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This article was written by a partner sports writer via Spotlight Sports Group. All odds displayed on this page were correct at the time of writing and are subject to withdrawal or change at any time.
