NFL Week 2: Schedule & Betting Odds presented by bet365

The NFL season rolls into Week 2 with another full slate of games, following an action-packed opening week. Here's the complete Week 2 schedule, including the betting odds for each matchup.

The Detroit Lions and Buffalo Bills open Week 2 with both teams entering Thursday night 1-0 after a pair of closely contested victories in their season openers. Detroit needed overtime to defeat the Saints 31-30, while Buffalo held off the Texans in a late fourth-quarter battle to win 36-31.

The matchup marks a milestone for the Bills, who will play their first regular-season game at the newly built Highmark Stadium when they welcome the Lions to New York.

There is plenty to look forward to in the NFL Week 2 slate, which wraps up on Monday night as the New York Giants face the Los Angeles Rams in California.

Lions @ Bills (TNF)

Date: Thursday, September 18, 2026
Time: 8:15 PM ET
Location: Highmark Stadium, Orchard Park, NY
Betting Odds:

	Spread	Total (O/U)	Money
DET Lions	+4.5 -105	O 54.5 -110	+190
BUF Bills	-4.5 -115	U 54.5 -110	-230

Panthers @ Falcons

Date: Sunday, September 20, 2026
Time: 1:00 PM ET
Location: Mercedes-Benz Stadium, Atlanta, GA
Betting Odds:

	Spread	Total (O/U)	Money
CAR Panthers	-2.5 -110	O 43.5 -110	-140
ATL Falcons	+2.5 -110	U 43.5 -110	+120

Bengals @ Texans

Date: Sunday, September 20, 2026
Time: 1:00 PM ET
Location: NRG Stadium, Houston, TX
Betting Odds:

	Spread	Total (O/U)	Money
CIN Bengals	+2.5 +100	O 46.5 -110	+125
HOU Texans	-2.5 -120	U 46.5 -110	-150

Browns @ Buccaneers

Date: Sunday, September 20, 2026
Time: 1:00 PM ET
Location: Raymond James Stadium, Tampa, FL
Betting Odds:

	Spread	Total (O/U)	Money
CLE Browns	+8.5 -110	O 41.5 -110	+325
TB Buccaneers	-8.5 -110	U 41.5 -110	-425

Packers @ Jets

Date: Sunday, September 20, 2026
Time: 1:00 PM ET
Location: MetLife Stadium, East Rutherford, NJ
Betting Odds:

	Spread	Total (O/U)	Money
GB Packers	-3.5 -110	O 44.5 -110	-200
NY Jets	+3.5 -110	U 44.5 -110	+165

Vikings @ Bears

Date: Sunday, September 20, 2026
Time: 1:00 PM ET
Location: Soldier Field, Chicago, IL
Betting Odds:

	Spread	Total (O/U)	Money
MIN Vikings	+5.5 -110	O 48.5 -105	+195
CHI Bears	-5.5 -110	U 48.5 -115	-240

Saints @ Ravens

Date: Sunday, September 20, 2026
Time: 1:00 PM ET
Location: M&T Bank Stadium, Baltimore, MD
Betting Odds:

	Spread	Total (O/U)	Money
NO Saints	+8.5 -110	O 47.5 -105	+325
BAL Ravens	-8.5 -110	U 47.5 -115	-425

Eagles @ Titans

Date: Sunday, September 20, 2026
Time: 1:00 PM ET
Location: Nissan Stadium, Nashville, TN
Betting Odds:

	Spread	Total (O/U)	Money
PHI Eagles	-7.0 -110	O 39.5 -110	-340
TEN Titans	+7.0 -110	U 39.5 -110	+270

Steelers @ Patriots

Date: Sunday, September 20, 2026
Time: 1:00 PM ET
Location: Gillette Stadium, Foxborough, MA
Betting Odds:

	Spread	Total (O/U)	Money
PIT Steelers	+5.5 -115	O 41.5 -110	+210
NE Patriots	-5.5 -105	U 41.5 -110	-260

Jaguars @ Broncos

Date: Sunday, September 20, 2026
Time: 4:05 PM ET
Location: Empower Field at Mile High Stadium, Denver, CO
Betting Odds:

	Spread	Total (O/U)	Money
JAX Jaguars	+2.5 +100	O 45.5 -110	+125
DEN Broncos	-2.5 -120	U 45.5 -110	-150

Raiders @ Chargers

Date: Sunday, September 20, 2026
Time: 4:05 PM ET
Location: SoFi Stadium, Inglewood, CA
Betting Odds:

	Spread	Total (O/U)	Money
LV Raiders	+6.5 -110	O 43.5 -110	+240
LA Chargers	-6.5 -110	U 43.5 -110	-300

Dolphins @ 49ers

Date: Sunday, September 20, 2026
Time: 4:25 PM ET
Location: Levi's Stadium, Santa Clara, CA
Betting Odds:

	Spread	Total (O/U)	Money
MIA Dolphins	+13.5 -115	O 45.5 -110	+600
SF 49ers	-13.5 -105	U 45.5 -110	-900

Seahawks @ Cardinals

Date: Sunday, September 20, 2026
Time: 4:25 PM ET
Location: State Farm Stadium, Glendale, AZ
Betting Odds:

	Spread	Total (O/U)	Money
SEA Seahawks	-4.5 +100	O 41.5 -105	-210
ARI Cardinals	+4.5 -120	U 41.5 -115	+175

Commanders @ Cowboys

Date: Sunday, September 20, 2026
Time: 4:25 PM ET
Location: AT&T Stadium, Arlington, TX
Betting Odds:

	Spread	Total (O/U)	Money
WAS Commanders	+3.5 +100	O 50.5 -110	+180
DAL Cowboys	-3.5 -120	U 50.5 -110	-220

Colts @ Chiefs (SNF)

Date: Sunday, September 20, 2026
Time: 8:20 PM ET
Location: Arrowhead Stadium, Kansas City, MO
Betting Odds:

	Spread	Total (O/U)	Money
IND Colts	+6.5 -105	O 46.5 -110	+240
KC Chiefs	-6.5 -115	U 46.5 -110	-300

Giants @ Rams (MNF)

Date: Monday, September 20, 2026
Time: 8:15 PM ET
Location: SoFi Stadium, Inglewood, CA
Betting Odds:

	Spread	Total (O/U)	Money
NY Giants	+7.5 -115	O 48.5 -110	+275
LA Rams	-7.5 -105	U 48.5 -110	-350

All odds written in this article were correct at the time of writing and are subject to change.

Discover more from bet365

Read the latest NFL news.