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The Colts are +375 to win the AFC South, +5000 to win the AFC, and +10000 to win the NFL Championship.
| Owner | Jim Irsay |
| General Manager | Chris Ballard |
| Head coach | Shane Steichen |
Player | Position | Height (ft) | Weight (lbs) | College |
Anthony Richardson | Quarterback | 6-4 | 244 | Florida |
Daniel Jones | Quarterback | 6-5 | 230 | Duke |
Jonathan Taylor | Running back | 5-10 | 226 | Wisconsin |
Michael Pittman | Wide receiver | 6-4 | 223 | USC |
Alec Pierce | Wide receiver | 6-3 | 211 | Cincinnati |
Josh Downs | Wide receiver | 5-9 | 171 | North Carolina |
Tyler Warren | Tight end | 6-5 | 256 | Penn State |
DeForest Buckner | Defensive tackle | 6-7 | 295 | Oregon |
Zaire Franklin | Linebacker | 6-0 | 235 | Syracuse |
Kenny Moore II | Cornerback | 5-9 | 190 | Valdosta State |
Week 1 | vs. Miami Dolphins |
Week 2 | vs. Denver Broncos |
Week 3 | @ Tennessee Titans |
Week 4 | @ Los Angeles Rams |
Week 5 | vs. Las Vegas Raiders |
Week 6 | vs. Arizona Cardinals |
Week 7 | @ Los Angeles Chargers |
Week 8 | vs. Tennessee Titans |
Week 9 | @ Pittsburgh Steelers |
Week 10 | vs. Atlanta Falcons |
Week 11 | BYE WEEK |
Week 12 | @ Kansas City Chiefs |
Week 13 | vs. Houston Texans |
Week 14 | @ Jacksonville Jaguars |
Week 15 | @ Seattle Seahawks |
Week 16 | vs. San Francisco 49ers |
Week 17 | vs. Jacksonville Jaguars |
Week 18 | @ Houston Texans |
| Championships won | 2 (1970, 2006) |
| Conference titles | 3 |
| Division titles | 15 |
| Playoff appearances | 24 |
| Passing yards | Peyton Manning | 54,828 yds |
| Passing touchdowns | Peyton Manning | 399 |
| Rushing yards | Edgerrin James | 9,226 yds |
| Rushing touchdowns | Edgerrin James | 64 |
| Receiving yards | Marvin Harrison | 14,580 yds |
| Receiving touchdowns | Marvin Harrison | 128 |
| Interceptions | Bobby Boyd | 57 |
| Sacks | Robert Mathis | 123 |