Newcastle will look to kick on from their 2-2 draw against Liverpool on Sunday when hosting West Bromwich Albion in the second round of the EFL Cup.
The Toon Army will have been encouraged by their performance against Andoni Iraola's outfit, twice going ahead before a stoppage-time penalty denied them all three points.
The Baggies meanwhile have started their season superbly, beating Rotherham 4-1 in the EFL Cup first round before recording 2-1 and 3-1 wins over Norwich City and Burnley respectively.
Wednesday's tie gives new manager Matthias Jaissle the opportunity to rotate his squad, but without that much depth to call upon, the Magpies should still field a strong side.
Jacob Murphy, Jacob Ramsey, Joe Willock and Fabian Schar should all be promoted to the starting XI, with Sven Botman, Lewis Miley, Anthony Elanga and Yoane Wissa making way.
Speculation around Nick Woltemade's future may keep the German out of the starting XI with William Osula starting a second consecutive game. Bazoumana Traore is in line to make his debut with Harvey Barnes dropping out.
Summer signing Aladji Bamba may make his full debut after coming off the bench for Sean Steur against Liverpool, while Leo Shahar could make his second Newcastle appearance after being named as a sub on Sunday.
Dan Burn, Tino Livramento and Joelinton all remain sidelined through injury.
Ewen Jaouen
Leo Shahar
Malick Thiaw
Fabian Schar
Lewis Hall
Aladji Bamba
Joe Willock
Jacob Ramsey
Jacob Murphy
Bazoumana Traore
William Osula
Odds displayed above correct at time of publishing and subject to change or withdrawal or any time.