Contenders from the AFC and NFC face off as Chicago Bears host New England Patriots in the early hours of Friday morning.
Both teams are coming off victories and will be looking to build momentum after a quick turnaround from their Sunday games.
Best Bet - Chicago Bears -2.5 @ 100/129
Alternative Bet - Drake Maye to throw an interception @ 10/13
Bet Builder - Chicago Bears moneyline, Colston Loveland anytime touchdown & Austin Booker to record a sack @ 7/1
Best Bet: Chicago Bears -2.5 @ 100/129
The Bears welcomed back quarterback Caleb Williams from a hamstring injury last week against Atlanta Falcons and picked up a 31-23 success which was more comfortable than the scoreline suggests.
A late turnover allowed the Falcons to put up 16 points in the fourth quarter, but, in reality, Chicago were always in control and they are fancied to follow that up with another success over the Patriots.
The Pats may have won three on the spin, but they have suffered both of their losses on the road and quarterback Drake Maye has a passer rating of 69.9 on the road, compared to 117.5 at home.
The Bears have the best rushing offense in the league and can exploit a New England team who are struggling with some injuries, particularly in their offensive line.
Expect the Bears to utilise their home advantage and cover the spread in this one.
Alternative Bet: Drake Maye to throw an interception @ 10/13
Patriots quarterback Maye has recovered from what was a shaky start to the season, but he may struggle to impose himself on this Bears team, particularly given the injuries in New England's offensive line.
Six of Maye’s seven interceptions this season have come away from Gillette Stadium and he looks a decent bet to throw another pick in this one.
Chicago Bears moneyline
Colston Loveland anytime touchdown
Austin Booker to record a sack
Pays 7/1
The Patriots may have won on their last four trips to Soldier Field, but this is a different Bears team to the ones which they have encountered in the past and there are concerns about the Pats’ form on the road, where they have suffered both of their losses this season.
Take Chicago on the moneyline.
Colston Loveland recorded his first touchdown of the season against the Falcons and with Williams back under centre, expect him to get plenty of the ball in this game. He looks a tempting price for a touchdown.
The Bears' Austin Booker has four sacks already this season and can pick up another against an injury-ridden Patriots offensive line.
Learn more about how Bet Builders work in our Bet Builder guide.
Chicago Bears have the best rushing offense in the NFL, averaging 160.7 yards per game
New England Patriots rank fifth in the league in points allowed at 18.8 per game
The Bears are 4-2 against the spread this season
Caleb Williams of the Bears had a career-high 83.3 completion percentage against Atlanta Falcons last time out
The Patriots rank 30th in turnover differential, having given up six more than they have gained
All three of Chicago's home games have seen the under hit
The Bears will be missing RB Kyle Monangai and LB Jack Sanborn through injury, while T.J. Edwards and Tyrique Stevenson Sr. are listed as questionable.
The Patriots will be without RG Ben Brown, LG Alijah Vera-Tucker, CB Carlton Davis III, CB Karon Prunty, and CB Channing Canada.
Morgan Moses, Kevin Byard III, Craig Woodson and Christian Ellliss are also listed as questionable for this game.
Read more NFL betting tips and predictions on site.
This article was written by a partner sports writer via Spotlight Sports Group. All odds displayed on this page were correct at the time of writing and are subject to withdrawal or change at any time.
Min deposit requirement. Free Bets are paid as Bet Credits and are available for use upon settlement of qualifying bets. Min odds, bet and payment method exclusions apply. Returns exclude Bet Credits stake. Time limits and T&Cs apply.