The Ukrainians picked up an impressive draw against PSV Eindhoven in their League Phase opener and head to Stamford Bridge as slight favourites, but AEK Athens FC are in good form and will fancy their chances on Wednesday.
The Greek side beat LASK Linz in their UEFA Champions League opener and made it to the UEFA Conference League quarter-finals last season.
Best Bet - AEK Athens FC draw no bet @ 5/6
Alternative Bet - Razvan Marin to score or assist @ 6/4
Bet Builder - Severino Isaque to score or assist, Luka Jovic 1+ shots on target, Lovro Majer 2+ fouls committed & Stavros Pilios 2+ fouls won @ 11/1
Best Bet: AEK Athens FC draw no bet @ 5/6
FC Shakhtar Donetsk are slight favourites for this tie, but they do not have an overly positive record in their designated home European games and AEK Athens FC will feel relatively confident about getting something from Stamford Bridge.
Despite making a run to the UEFA Conference League semi-finals last season, the Ukrainians have managed only two wins from their last eight European home games, with much of their successful campaign coming from impressive away showings.
AEK Athens FC made it to the quarter-finals of the UEFA Conference League last season and, after their win over LASK Linz last month, they have now lost just three of their last 19 European matches.
That includes three wins from their last six continental away games and, with the Greek side unbeaten in competitive football this season and winning eight of their 12 outings, they look a good bet in London.
Alternative Bet: Razvan Marin to score or assist @ 6/4
Razvan Marin’s assist for AEK Athens' second goal against OFI Crete on Saturday was his seventh goal contribution of the season and the Romania international looks good value to add another to his tally on Wednesday.
He has either scored or assisted in six of his last eight appearances for the club and scored the winner against LASK Linz in the UEFA Champions League last month.
Marin scored seven goals and assisted nine more for AEK Athens last season and his excellent form could be set to continue against FC Shakhtar Donetsk.
Severino Isaque to score or assist
Luka Jovic 1+ shots on target
Lovro Majer 2+ fouls committed
Stavros Pilios 2+ fouls won
Pays 11/1
While AEK Athens FC are predicted to perform well, they have conceded seven goals in their last five European away games and may be vulnerable against FC Shakhtar Donetsk, with Severino Isaque standing out as a major threat for the hosts.
The Brazilian teenager has registered four combined goals and assists this season, averaging a goal contribution every 104 minutes, and he played creator for Gleiker Mendoza’s opener against PSV Eindhoven last month.
AEK Athens FC will look to Serbian star Luka Jovic for a lot of their attacking play, with the striker hitting the target with 10 of his 20 shots this season.
He has had at least one shot on target in seven of his last eight games for the club, including one against LASK Linz in this competition.
Team-mate Lovro Majer leads the AEK charts for fouls committed and has been reprimanded at least nine times in his last five games, while Albanian left-back Stavros Pilios has drawn two or more fouls in eight of his last 11 appearances for club and country.
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FC Shakhtar Donetsk have won just two of their last eight European home matches
AEK Athens FC have lost only two of their nine European away games since the start of last season
Stavros Pilios has been fouled twice or more in eight of his last 11 games for AEK Athens FC and Albania
Luka Jovic has registered a shot on target in seven of his last eight games
Severino Isaque has averaged a goal contribution every 104 minutes this season
Razvan Marin has either scored or assisted in six of his last eight games
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This article was written by a partner sports writer via Spotlight Sports Group. All odds displayed on this page were correct at the time of writing and are subject to withdrawal or change at any time.