The reigning World Champions will visit Wembley on Saturday as England take to the pitch for the first time since their World Cup heartbreak.
Spain conceded just once across eight games in North America this summer, claiming the World Cup for the second time in history by beating Argentina 1-0 in the final.
In doing so they became the first country to simultaneously hold the World Cup and European Championship on two occasions, but Luis de la Fuente's ambition has shown no signs of slowing down.
La Roja make their way to the capital in the midst of an incredible unbeaten run, having gone 38 games without defeat in all competitions.
Interestingly their last loss did come on British soil, though not against the Three Lions.
A 1-0 defeat to Colombia at the London Stadium all the way back in March 2024 marked the last time Spain tasted defeat, and Thomas Tuchel will be determined to upset the odds on Saturday night.
The former Chelsea boss made a number of changes ahead of the UEFA Nations League fixtures, with the likes of Trent Alexander-Arnold, Rio Ngumoha and Alex Scott all returning to the fold.
A number of injuries have forced Tuchel to make changes however, with no fewer than five players withdrawing in recent days.
James Garner and Morgan Gibbs-White have been drafted in on short notice to plug the gaps, and both will be hoping to feature at the national stadium this weekend.
Unsurprisingly Spain are the favourites to secure victory on Saturday night, with the world champions priced at 13/10 to claim all three points.
Harry Kane became England's all-time record World Cup goalscorer this summer and the Bayern Munich talisman is 6/4 to continue his impressive form by getting on the scoresheet at any time.
Both teams are blessed with firepower going forward and only once in 29 meetings between the two countries have both sides failed to find the net.
Both goalkeepers to keep a clean sheet in a goalless draw is priced at 11/1.
England v Spain Betting Odds
(Odds will display when markets are available)
Odds displayed correct at time of publishing and subject to change or withdrawal at any time.
