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Brewers vs. Padres: Prediction, Props & Best Bets

Milwaukee Brewers and San Diego Padres are set for a Monday night matchup at Petco Park in San Diego.

The Brewers enter this contest leading the NL Central by 5.5 games over the Cubs.

Milwaukee’s 74 wins are the most in the National League, and they are looking to keep their foot on the gas in this series against San Diego.

The Padres own an overall record of 62-57, which puts them a single game back in the National League wild card hunt.

Winning this series at home could be pivotal to their playoff chances and first pitch on Monday night is set for 9:40 p.m. ET.

Milwaukee Brewers vs. San Diego Padres betting picks and predictions

Brewers ML (-110)

In addition to owning the best record in the NL, the Brewers enter this west coast matchup with wins in five of their last six games.

After a strong seven-game home stand against the Pirates and Twins, the Brewers now hit the road where they are 33-22 for the season. 

Milwaukee will hand the ball to left-hander Logan Henderson. The 24-year-old has been impressive in 2026, especially since returning to the rotation in early July.

Since his start against the Cardinals on July 9, Henderson has allowed just 17 hits and eight earned runs over 27.0 innings of work.

He’s also racked up 32 strikeouts to go along with just four walks in that span. 

Those performances have put his team in a great position to win, as the Brewers are 5-0 in those outings and have won each of his last eight starts.

On the season, Milwaukee is 8-2 when Henderson toes the rubber.

Henderson seems to have a favorable matchup in this one, as the Padres have struggled to hit left-handed pitching all season long.

Specifically, San Diego ranks 27th in MLB with a team OPS of .672 against southpaws. 

San Diego have Casey Mize, who came over from the Tigers at the trade deadline, and had a rough first outing with his new team.

Last week against the Diamondbacks, Mize allowed eight earned runs on nine hits over the course of just 3.1 innings.

The Padres lost 10-4, and Mize faces another tough challenge in this one against Milwaukee.

The Brewers are the team to back on the moneyline. 

Under 7.5 (-120)

As previously mentioned, the Padres have struggled offensively when going up against left-handed pitchers this season.

Henderson has been in a major groove over the last month, and he is throwing a ton of strikes. He rarely issues free passes and does a good job of attacking the strike zone.

That approach is exactly what is needed when going up against this Padres lineup.

As long as Henderson maintains his accuracy and doesn’t get himself into problems with free passes, he should be able to limit the damage from the San Diego offense.

Mize struggled mightily in his first start with the Padres, but he is more than capable of bouncing back.

He posted a strong 2.70 ERA, to go along with a 0.99 WHIP over 86.2 innings with the Tigers before being traded.

He’s in the midst of the best season of his career and, despite his first start with San Diego not going his way, his body of work this season shows that performance is a bit of an outlier. 

It’s also worth noting that both of these bullpens are elite. Milwaukee ranks 4th in all of baseball with a 3.49 bullpen ERA, while San Diego isn’t far behind ranking 5th with a bullpen ERA of 3.65. 

All in all, runs could be at a premium in this one. Look to the under.

Read more betting picks and predictions for the MLB on site

Milwaukee Brewers vs. San Diego Padres odds

Brewers

-110

Padres

+100

Run Line

SD Padres +1.5

Total

O/U 7.5

Milwaukee Brewers vs. San Diego Padres player props

Home runs

Manny Machado (SD Padres)

+390

Jackson Chourio (MIL Brewers)

+450

Jackson Merrill (SD Padres)

+450

Fernando Tatis Jr. (SD Padres)

+450

Jake Bauers (MIL Brewers)

+490

Ty France (SD Padres)

+525

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This article was written by a partner sports writer via Spotlight Sports Group. All odds displayed on this page were correct at the time of writing and are subject to withdrawal or change at any time.

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