Nissan Stadium in Nashville, TN, will host the Week 1 matchup between Louisville and Ole Miss on Sunday night.
Week 1 showcases the No. 24 Louisville Cardinals and the No. 9 Ole Miss Rebels in an important matchup for both programs. Securing a ranked victory the first week of the season would be a great place to start.
Pete Golding enters his first season as the head coach at Ole Miss. Golding arrives to his first regular season start after a dominant playoff run defeating Tulane and Georgia. While Jeff Brohm guided the Cardinals to a regular season victory over the Miami Hurricanes - the same team that eliminated Ole Miss from the playoffs.
Louisville acquired wide receiver Tre Richardson from Vanderbilt via the transfer portal during the offseason. Richardson has quickly established himself as a primary target in the Cardinals offense, coming off a stellar 2025 season, where he had 46 receptions for 806 yards, and 7 touchdowns over 13 games making him a threat to the Ole Miss secondary.
To counter Louisville's offensive threats, the Rebels have brought in new a new linebacker duo - Keaton Thomas, transferring from Baylor, and Luke Ferrelli, from Cal. Both are expected to make their first starts against the Cardinals, hoping to address the defensive gaps that hindered Ole Miss against powerful running teams last season.
Kickoff Time & How to Watch
The Louisville Cardinals will face the Ole Miss Rebels on Sunday, September 6. Kickoff is scheduled for 7:30 PM ET (6:30 PM CT).
In the United States, the game will broadcast live on ABC or it can be streamed on the ESPN APP and Fubo.
Louisville vs. Ole Miss Odds
Spread | Total (O/U) | Money Line | |
Louisville | +6.5 +100 | O 55.5 -110 | +225 |
Ole Miss | -6.5 -120 | U 55.5 -110 | -275 |
First Team to Score
Louisville +115 | Ole Miss -155 |
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All odds written in this article were correct at the time of writing and are subject to change.
