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Detroit Lions vs. Buffalo Bills
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Lions vs. Bills: Betting Odds on Thursday Night Football

The Bills host the Lions in the first game at Highmark Stadium on Thursday Night Football.

Game

Detroit Lions vs. Buffalo Bills

Date

Thursday, September 17

Kickoff Time

8:15 p.m. ET / 7:15 p.m. CT

Stadium

Highmark Stadium, Orchard Park, NY

TV Channel

Prime Video

The Buffalo Bills will play their first game at the newly built Highmark Stadium in Orchard Park, NY on Thursday Night.

The Bills are coming off a great 36-31 win against the Houston Texans, where Josh Allen passed for 334 yards and two touchdowns while rushing for two more.

Buffalo's new offseason acquisition, DJ Moore, also had a great game. In his first game as a Bill, Moore caught five passes for 100 yards and touchdown.

The Bills offense looked great again even against the vaunted Houston defense, but this week they face another high-powered offense from Detroit.

Detroit got the OT win against the New Orleans Saints in Week 1, and their offense picked up where they've left off the past few years.

Jahmyr Gibbs is one of the best running backs in the NFL, and proved it by by rushing for 156 yards and two touchdowns on 29 carries.

Amon-Ra St. Brown was also incredible for Jared Goff in the passing game, catching 10 of his 14 targets for 67 yards and two touchdowns.

Both offenses looked great in week one, which could set up a very high scoring game on Thursday Night Football.

Lions vs. Bills Betting Odds

All odds written in this article were correct at the time of writing and are subject to change.

Spread, Total, Money

Spread

Total

Money

DET Lions

+4.5 +105

O 54.5 -110

+190

BUF Bills

-4.5 -115

U 54.5 -110

-230

Odds presented by bet365

Touchdown Scorer Odds

First TD

Anytime TD

Jahmyr Gibbs (DET)

+255

-315

James Cook (BUF)

+450

-160

Josh Allen (BUF)

+500

-140

Amon-Ra St. Brown (DET)

+700

+110

DJ Moore (BUF)

+1000

+160

Dalton Kincaid (BUF)

+1100

+175

Jameson Williams (DET)

+1300

+200

Sam LaPorta (DET)

+1400

+220

Khalil Shakir (BUF)

+1400

+220

Keon Coleman (BUF)

+2500

+390

Ray Davis (BUF)

+2500

+425

Dawson Knox (BUF)

+3000

+475

Isaac TeSlaa (DET)

+3500

+575

Josh Palmer (BUF)

+3500

+550

Jahmyr Gibbs Rushing Props

Over

Under

90.5 Rushing Yards

-110

-120

19.5 Rushing Attempts

-110

-120

18.5 Yard Longest Rush

-115

-115

100+ Rushing Yards

+135

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