Buffalo Bills vs. Houston Texans: Preview & Betting Odds

Cameron Kelly Updated: 4 hours ago

For the third straight season, the Buffalo Bills head to Houston looking to get back in the win column after losing their last two matchups against the Texans.

Game	Buffalo Bills @ Houston Texans
Date	Sunday, September 13, 2026
Time	1:00 PM ET / 12:00 PM CT
Stadium	Reliant Stadium, Houston, TX
TV Channel	CBS

The Buffalo Bills enter a new era with Joe Brady as head coach, following his tenure as the team's offensive coordinator. This is not the only coaching change the Bills have made this offseason; Jeff Leonhard is making his defensive coordinator debut for the Bills, previously working for the Denver Broncos.

Josh Allen's ability to move the ball down the field using running back James Cook, combined with the new addition of wide receiver DJ Moore, will be an early test for the Houston defense.

DeMeco Ryans returns for his fourth year with the Houston Texans and quarterback C.J. Stroud leads the Texans offense that will hope to find better consistency this season. The Texans had one of the top performing defenses in 2025 and they have only gotten stronger adding Reed Blankenship and Logan Hall to the roster.

Defensive end Will Anderson Jr. and Houston's pass rush have the ability to disrupt Josh Allen, putting pressure on the Bill's offensive line. After allowing eight sacks to the Texans in last years matchup, Buffalo will be sure to not let history repeat itself.

Bills vs. Texans Odds

	Spread	Total	Money Line
Bills	-1.0 -120	O 44.5 -115	-120
Texans	+1.0 +100	U 44.5 -105	+100

Touchdown Scorer Odds

	First TD	Anytime TD
David Montgomery	+425	-120
James Cook	+450	-110
Josh Allen	+600	+120
Nico Collins	+750	+145
Woody Marks	+900	+185
DJ Moore	+1250	+260
Dalton Shultz	+1250	+245
Dalton Kincaid	+1300	+265
Khalil Shakir	+1300	+265