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Atlanta Braves vs. San Diego Padres: Prediction, Props, & Best Bets (6/22)

Atlanta Braves (48-28, 24-14 away from home, 1st in NL East, +97 run differential) travel to San Diego, California to begin a series against the Padres (39-37, 19-19 at home, 2nd in NL West, -10 run differential).

This will be the first of seven games between these squads in 2026. The second series will be a four-game set in Atlanta, beginning on July 20.

The Braves arrive on the heels of a big series win at home over the first-placed Milwaukee Brewers, while the Padres return home from a 2-4 road trip, most recently losing in Texas over the weekend against the Rangers.

Atlanta has been steady in the betting market, entering 44-32 against the run line, and 37-35-4 on Over/Unders. The Padres have been better against the run line than they have winning games, arriving 42-34 against the run line, with the Under on the run total dominating their games, hitting 43 times.

First pitch is at 10 PM ET Monday night, as Grant Holmes squares off against Michael King on the mound.

Atlanta Braves vs. San Diego Padres betting picks and predictions

San Diego Padres ML (-110)

The Braves travel cross-country without a day of rest and send a pitcher to the mound who owns a 6.17 ERA in June, and who has failed to complete four innings in either of his last two starts, combining to allow six runs in that stretch.

Holmes has also been worse pitching on the road, and far worse at night, with a 4.70 ERA compared to a 3.65 ERA during day games. In 21 career at-bats against Holmes, Padres hitters are 7-for-21 with two doubles, two RBIs, two walks and four strikeouts.

Michael King hasn’t been much better than Holmes in June, pitching to a 5.29 ERA in three starts while allowing three earned runs in all three outings. However, King owns a 3.30 ERA at home on the season, and he doesn’t have a particular vulnerability against left-handed or right-handed hitters.

Most importantly, the Braves are just 16-for-66 lifetime against the Padres with two doubles, one home run and four walks to 20 strikeouts. The Braves might be top 10 in baseball by OPS on the road, OPS at night and OPS vs right-handed pitching, but Petco Park is a pitcher’s park through and through, and the Padres have the far better starting pitcher in this matchup.

This is a big series for the Padres at home to prove to themselves and the rest of the league that they belong in the playoffs. On national television, the Padres can win a tight, low-scoring game in what oddsmakers have decided is a coin flip.

Under 7.5 total runs (-127)

I don’t care how poorly Holmes and King have pitched in June, this game screams Under. Ronald Acuna Jr. remains on the IL, and while he hasn’t been up to his normal standard at the plate in 2026, he is the freakish tone setter that leads things off for that dangerous Braves lineup. Without his presence from the jump and without him lurking in the latter innings, the Padres’ elite pitching staff has a huge burden lifted from its shoulders.

The Padres rank dead last in baseball by OPS at home, OPS at night and OPS vs right-handed pitching, and yet they win games at home due to pitching and defense. Opposing teams aren’t hitting well in San Diego either, as Petco ranks 24th among all MLB parks in Statcast’s Park Factor (97).

Also, we can’t forget that by ERA, these are the two best bullpens in baseball. The Padres rank second with a 3.09, and the Braves top baseball with a 2.87. The Padres also have the best closer in Mason Miller.

This matchup also features two of the biggest underperforming hitters in all of baseball. Third basemen Manny Machado and Austin Riley are severely struggling with career low numbers across the board at the plate. Without their typical middle-of-the-order thump, this matchup is a little less threatening to the scoreboard.

Manny Machado to hit a home run (+475)

The single best offensive metric at Petco Park in 2026 has been home run rate, with a solid 107 score in that department, meaning there are 7% more home runs in Petco relative to league average.

To somewhat contradict my note on Machado above, I will take him to hit a home run today. While he may be hitting .179 with a .625 OPS, he does lead the team with 13 home runs, and 10 of his long balls have come against right handers.

Also, while an extremely small sample, he sees Holmes well, going 2-for-2 against him in his career. Machado is 4-for-16 over his last four games with three extra-base hits, including a home run.

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Atlanta Braves vs. San Diego Padres odds

Atlanta Braves

-110 ML

San Diego Padres

-110 ML

Run Line

Braves -1.5

Total

O/U 7.5

Atlanta Braves vs. San Diego Padres player props

Player home run odds

Drake Baldwin (ATL Braves)

+325

Matt Olson (ATL Braves)

+350

Fernando Tatis Jr. (SD Padres)

+390

Michael Harris II (ATL Braves)

+450

Manny Machado (SD Padres)

+475

Gavin Sheets (SD Padres)

+500

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This article was written by a partner sports writer via Spotlight Sports Group. All odds displayed on this page were correct at the time of writing and are subject to withdrawal or change at any time.

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