Liverpool will look to extend their perfect record in the UEFA Champions League when travelling to Fenerbahce.
The Reds have been in free-scoring form in the UEFA Champions League this season, scoring 12 goals in their three outings so far.
They will however need to bounce back from a frustrating encounter with Arsenal in the Premier League last time out.
Having gone behind in the first half, Liverpool dominated possession for much of the remainder of the match but were unable to break down a resolute Arsenal defence, ending a five game unbeaten run in all competitions.
Fenerbahce v Liverpool team news
Andoni Iraola has taken the opportunity to rest some of his key players for the trip to Turkey, but the bare nature of Liverpool's squad has led to a fairly significant shake-up.
Nevertheless, the Liverpool boss has rotated his two first-choice full-backs out, with Joe Gomez and Kostas Tsimikas deputising.
Florian Wirtz starts on the bench with Dominik Szoboszlai occupying the number 10 role, with Bradley Barcola entrusted to lead the line in place of Alexander Isak, with Rio Ngumoha and Victor Munoz handed starting berths on the wings.
Confirmed Liverpool line-up
Alisson
Joe Gomez
Jeremy Jacquet
Virgil van Dijk
Kostas Tsimikas
Alexis Mac Allister
Trey Nyoni
Rio Ngumoha
Dominik Szoboszlai
Victor Munoz
Bradley Barcola
Substitutes: Mamardashvili, Woodman, Kerkez, Wirtz, Isak, Gakpo, Araujo, Chambers, McConnell, Koumas, Danns
