Switzerland are bidding to reach the quarter-finals of the World Cup for the first time since 1954, but they face a huge task against a formidable Colombia outfit in Vancouver.
Both sides could be filed in the World Cup dark horses category, with the Swiss advancing to this stage with few problems, while Los Cafeteros have also made steady progress up till now.
Best Bet - Colombia to win @ 13/10
Alternative Bet - Under 2.5 goals @ 4/7
Bet Builder - Colombia to win, Breel Embolo 2+ shots and Luis Diaz 3+ shots @ 6/1
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Best Bet - Colombia to win @ 13/10
Colombia finished top of their group after seeing off Uzbekistan and DR Congo, while they largely dominated a goalless draw with the much-respected Portugal too.
Then, in the last-32, another typical gutsy display saw off a defensive-minded Ghana 1-0.
This is a stiffer test against the often underestimated Swiss but it's one the South Americans should pass.
Colombia, who are 11th, are ranked just four places higher by FIFA than their opponents on Tuesday, so that suggests it could be a tight affair.
The two sides' respective form in North America also confirms suspicions that there may not be much between them, with a World Cup quarter-final spot up for grabs.
Murat Yakin's side began the tournament with a shock draw against Qatar, before displaying their quality in a 4-1 win over Bosnia-Herzegovina.
A final 2-1 win over co-hosts Canada was impressive, and sealed top spot before they outclassed Algeria 2-0 in the last round.
The European nation are very well drilled and will know how to try and keep Colombia quiet. However, a side containing Bayern Munich's Luis Diaz, Palmeiras' Jhon Arias, Luis Suarez of Sporting Lisbon and Crystal Palace pair Daniel Munoz and Jefferson Lerma should find that extra sparkle to win.
Alternative Bet - Under 2.5 total goals @ 4/7
Goals have not flowed for Colombia in the tournament. Instead - aside from their opening 3-1 win over debutants Uzbekistan - they have had to grind things out.
A 1-0 win over DR Congo and the goalless draw with Portugal were solid results, as was the similar last-32 success over Ghana, and they could use the same template against a Swiss side likely to be guarded going forward.
Switzerland have not really cut loose in an attacking sense either - aside from the convincing group win over a weak Bosnia - leading us to believe this last-16 showdown will be tight with a strong chance of there being under three goals scored.
Colombia to win
Breel Embolo 2+ shots
Luis Diaz 3+ shots
Pays @ 6/1
The starting point for the Bet Builder is for a Colombia victory and then adding in a key forward for each side to impress boosts the selection.
Breel Embolo has been one of the Swiss' best players this summer, scoring twice and contributing two assists, while the Rennes man has generally been lively in and around the penalty area, taking eight shots so far in the first four games.
Against Qatar he had four, then versus Bosnia he managed just one, before having two shots against both Algeria and Canada.
Luis Diaz is probably Los Cafeteros' best-known player with the former Liverpool man offering pace, trickery and a goal threat.
He got a goal and an assist in the first match against Uzbekistan and, in total, has had 16 shots in four games.
Diaz only had two in that opener, before firing five goalward against DR Congo, then four versus Portugal and five again in the last-32 win over Ghana.
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Switzerland are unbeaten in seven games
The Swiss have only lost one of their last 18 matches - a 4-3 friendly defeat to Germany in March
Colombia have won five of their last six matches, drawing the other
Los Cafeteros have only lost two of their last 17 games
Colombia's best performance in the World Cup came in 2014 when they reached the quarter-finals
Switzerland's best run in the tournament was in 1954 when they also made it to the last eight
Switzerland have been knocked out in the last 16 in the last three editions
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This article was written by a partner sports writer via Spotlight Sports Group. All odds displayed on this page were correct at the time of writing and are subject to withdrawal or change at any time.