Santos looked like they were starting to crack it before Sunday's 3-0 home defeat to Coritiba and will aim to bounce back when San Lorenzo visit in the Copa Sudamericana on Wednesday.
After losing their Group D opener 1-0 to Deportivo Cuenca, Santos have drawn their next three games 1-1, including in Buenos Aires on 28th April.
San Lorenzo also drew their last game against Deportivo 0-0 in Ecuador, but despite topping the pool and being unbeaten, they have only won once, drawing three others.
They have had 10 days to prepare since their agonising Apertura play-off penalty shoot defeat at River Plate and could set out to frustrate their hosts.
Best Bet - Draw @ 5/2
Alternative Bet - Gabriel Barbosa to score @ 7/4
Bet Builder - Rodrigo Auzmendi to Score, Alexis Cuello: 2+ Fouls Won and Goals Range 1-4 @ 13/2
Best Bet - Draw @ 5/2
The headlines about Neymar reportedly being wrongly substituted by the officials masked how bad Santos were against Coritiba.
San Lorenzo should set out to try and frustrate their opponents and get the crowd to turn again at the Estadio Urbano Caldeira.
Avoiding defeat on the road suits them and a point will put them in prime position ahead of next week's final Group D game against Paraguay's Recoleta.
The draw appeals between these teams after last month's 1-1 at the Nuevo Gasometro, a scoreline which is 11/2 to be repeated.
They have each drawn three times in the pool, and a point apiece appeals.
Alternative Bet - Gabriel Barbosa to score @ 7/4
There are doubts over Neymar's participation, as despite the questions over his weekend substitution, he did limp off and is reportedly struggling with a knock.
Gabriel Barbosa could come into the side, and head coach Cuca could favour a horses-for-courses approach after the former Inter Milan man's goal in Buenos Aires.
The 29-year-old has never lived up to his potential, but remains a talented operator and may grab another goal on Wednesday.
Rodrigo Auzmendi to score
Alexis Cuello: 2+ Fouls Won
Goals Range 1-4
Pays 13/2
San Lorenzo's threat could be carried by Rodrigo Auzmendi, who has scored three times in his last five games.
Colleague Alexis Cuello, who netted for Los Cuervos in the reverse game, has suffered 11 fouls in this competition and could draw more attention after the previous fixture tallied 17 fouls.
Finally, like that 1-1, a goal range of between 1-4 appeals, with four or fewer scored in 19 of Santos' last 20 games.
Learn more about how Bet Builders work in our Bet Builder guide.
Both teams have drawn three of their four games in this season's Copa Sudamericana
All of those matches have finished 1-1
Gabriel Barbosa scored Santos' goal in April's draw
San Lorenzo's Rodrigo Auzmendi has scored three times in his last five away games
Teammate Alexis Cuello has been fouled 11 times in the Copa Sudamericana
Of Santos' last 20 games, 19 have featured four or fewer goals
Read more football betting tips and predictions on site.
This article was written by a partner sports writer via Spotlight Sports Group. All odds displayed on this page were correct at the time of writing and are subject to withdrawal or change at any time.
FOOTBALL
Copa Sudamericana: Previous winners
Find out every winner of the Copa Sudamericana since its inception in 2002.
Liam Williams
24 Nov 25
FOOTBALL
Real Madrid 2009/10 - Most Matches
Get the list of the top 10 players who played the most matches for Real Madrid during the 2009/10 season.
Matt Gibbs
3 hours ago