The Netherlands and Germany are the favourites to progress from Nations League Group A2 and they meet in Thursday's opening game in Amsterdam.
Both countries exited the World Cup in the Last 32, prompting changes of manager.
Spain legend Xavi succeeded Ronald Koeman as Dutch coach while Jurgen Klopp has replaced Julian Nagelsmann as Germany boss.
Netherlands lost to Portugal in the inaugural Nations League final in 2018/19 and Germany were beaten by the same opponents in the 2024/25 semi-finals.
Best Bet - Netherlands to win @ 6/4
Alternative Bet - Cody Gakpo to be first goalscorer @ 13/2
Bet Builder - Over 2.5 goals, Kai Havertz to score & Felix Nmecha 1+ shot on target @ 11/2
Best Bet: Netherlands to win @ 6/4
Netherlands lost on penalties to an excellent Morocco side in the World Cup round of 32, having scored 10 goals in three group games against Japan, Sweden and Tunisia.
In-form Roma forward Donyell Malen has pulled out of the Dutch squad but they still have enough firepower to beat an experimental Germany side.
New manager Jurgen Klopp called up 44 players, split into two separate squads, for Germany's first four Nations League matches.
That selection policy could lead to a disjointed performance in Amsterdam, where the Netherlands look a decent bet to take three points.
There should be plenty of goals as the Oranje scored 16 times in their last five 2026 World Cup qualifiers, having beaten Bosnia 5-2 and Hungary 4-0 at home in the 2024/25 Nations League.
Their other home result in the group stage was a 2-2 draw with Germany, and their run only ended with a penalty shootout defeat to Spain after a 5-5 aggregate draw in the quarter-finals.
Few teams trouble the world and European champions to that extent, and the Netherlands can make the most of home advantage against Germany.
Die Mannschaft were knocked out on penalties by last-32 underdogs Paraguay in Julian Nagelsmann's final game in charge.
They had thrashed Curacao 7-1 in their tournament opener but needed a late winner against Ivory Coast on matchday two before losing 2-1 to Ecuador.
Alternative Bet: Cody Gakpo to be first goalscorer @ 13/2
Netherlands forward Cody Gakpo has excelled at his last two major tournaments and he should be backed to open the scoring against Germany.
Gakpo was the joint-leading scorer at Euro 2024 with three goals and he struck three times in four starts at the World Cup.
He was linked with a move to Manchester City late in the summer transfer window but ultimately stayed at Liverpool.
There has been no sign of a World Cup hangover in his early-season performances as he scored in the Premier League draw at Newcastle and last week's EFL Cup win over Tottenham.
In the 2024/25 Nations League, Gakpo found the net in three of his four home appearances – against Bosnia, Hungary and Spain – and he could be too sharp for a new-look Germany defence.
Over 2.5 goals
Kai Havertz to score
Felix Nmecha 1+ shot on target
Pays 11/2
Over 2.5 goals was a winning bet in six of the last eight meetings between Netherlands and Germany and both teams have been short of clean sheets this year.
Kai Havertz has made a bright start to the 2026/27 campaign for Arsenal and the Germany forward scored four goals in his last five internationals.
Midfielder Felix Nmecha took less than six minutes to open the scoring in Germany's first World Cup game against Curacao.
He had eight shots in three group matches and has struck twice in his first three Bundesliga starts for Borussia Dortmund this term.
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The Netherlands opened the scoring in six of their last seven matches
Cody Gakpo has scored five times in his last five international appearances
The Dutch have won only one of their last seven meetings with Germany
Both teams scored in seven of Germany's last eight internationals
Germany have won 11 of their last 13 games
Joshua Kimmich provided five assists in his last four Nations League appearances
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This article was written by a partner sports writer via Spotlight Sports Group. All odds displayed on this page were correct at the time of writing and are subject to withdrawal or change at any time.