Colombia can make it into the last 16 of the World Cup with victory over Ghana in Kansas City during the early hours of Saturday morning.
Colombia are unbeaten, posting group wins over Uzbekistan and DR Congo alongside a creditable 0-0 draw with Portugal.
Ghana, meanwhile, progressed to the knockout stage following a narrow, late win over Panama, a solid goalless outing against England and a final 2-1 defeat against Croatia.
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Best Bet - Under 2.5 goals @ 4/6
Alternative Bet - Luis Diaz 2+ shots on target @ 7/4
Bet Builder - Half-time/Full-time - Colombia/Colombia, Colombia to have most corners, most shots and most shots on target @ 13/4
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Best Bet: Under 2.5 goals @ 4/6
Colombia are tipped to progress but it is unlikely to be a rip-roaring success for the South Americans and instead a low-scoring encounter is expected in Kansas City.
After overcoming weak opponents Uzbekistan 3-1 in their Group K opener, Colombia had to wait until the 76th minute before seeing off DR Congo, winning 1-0, before they ground out a goalless draw with European heavyweights Portugal.
Ghana got through thanks largely to their win over Panama but that was only achieved by an injury-time effort.
They then demonstrated plenty of defensive resolve, while also offering a threat on the counter-attack, when holding England to a gutsy 0-0 draw.
It will probably have to be a similar resolute display from the Africans if they are to upset the odds in the early hours of Saturday and knock out Colombia, but Carlos Queiroz's side do not look capable of stepping up their game when they need it most.
Los Cafeteros, in contrast, should be able to move up the gears and they can control this last-32 clash, even if they may have to rely on a tight victory in the end to see them over the line.
There is little value in backing a Colombia win at 1/2 so instead go for under 2.5 goals at 4/6.
Ghana have only scored two goals in their three games at the tournament, while Colombia have five, although they have come against poorer opposition than this.
Alternative Bet: Luis Diaz 2+ shots on target @ 7/4
Bayern Munich winger Luis Diaz remains Colombia's main man and he has had a decent World Cup so far, scoring and assisting in the win over Uzbekistan.
Overall, the former Liverpool man has been lively, accruing 11 shots in three appearances, managing two in the first game, five in the second against DR Congo and then four in the Portugal clash.
Even though Diaz has only had three shots on target among those 11, the 29-year-old is backable to test the goalkeeper at least twice on Saturday.
Diaz is often the man for the big occasion for club and country and he should be in and around Colombia's best attacking moments.
Half-time/Full-time - Colombia/Colombia
Colombia to have most corners
Colombia to have most shots
Colombia to have most shots on target
Pays 13/4
This may not be a totally dominant Colombia victory but they are expected to be the better side from the off and can generally dictate things in Kansas City.
Backing Colombia to be in front at half-time, therefor, seems logical before they then go on to seal their place in the last 16.
Adding in the favourites to also win the corner, shot and shots on target count boosts the Bet Builder considerably.
It is interesting to note Colombia have posted higher shots on target and shots figures than their opponents in all three games so far.
Meanwhile, in contrast, Ghana have lost on both of those metrics in each of their three outings in the tournament.
Tellingly, Ghana had fewer shots and shots on target against Panama, despite winning, then fewer against Croatia in the 2-1 defeat, and also against England in between, when the Three Lions were the much more dominant attacking side.
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Colombia are ranked 11th by FIFA
Ghana are down in 65th place in the world rankings
Both teams' best World Cup showing is reaching the last eight - Ghana in 2010 and Colombia in 2014
Colombia have won four of their last five games
Ghana have only won one of their last nine matches
The two countries have never played each other before
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This article was written by a partner sports writer via Spotlight Sports Group. All odds displayed on this page were correct at the time of writing and are subject to withdrawal or change at any time.