Argentina strolled to an emotional 3-0 win over Benin in October, where Lionel Messi played a part in all three goals in his final game before retiring from international football.
Now, the likes of Julian Alvarez and Thiago Almada will look to take up the mantle and beat a visiting Uruguay side who won their last two friendlies of the September international break convincingly.
Argentina v Uruguay Tips Summary
Best Bet - Argentina to win to nil @ 5/4
Alternative Bet - Nico Paz to score or assist @ 11/10
Bet Builder - Julian Alvarez 3+ shots, Federico Valverde 1+ shots on target, Enzo Fernandez 2+ shots @ 4.6/1
Argentina v Uruguay Prediction
Best Bet: Argentina to win to nil @ 5/4
Argentina may lack a replacement for the retired Messi, but their defence remains a solid outfit and they look good value to shut out Uruguay en route to a victory on Friday.
La Albiceleste have won their last three games by an aggregate scoreline of 14-0 and the last goal they conceded in regulation time came against England in the World Cup semi-finals.
They have beaten Uruguay in four of their last five encounters and have kept a clean sheet in each of those victories, while the visitors failed to win any of their group stage games in the summer World Cup.
Alternative Bet: Nico Paz to score or assist @ 11/10
Nico Paz made his Argentina debut in 2024 but the Como attacker has really stepped up in recent times, scoring all four of his international goals in his eight appearances in 2026.
He found the net in all three friendlies during the last international break and added an assist to his tally, too, while he has been in phenomenal form for his club this season.
He has registered 10 combined goals and assists in his eight games since the last international break, taking his tally to 18 goal contributions for club and country this season. Back him to punish the visitors.
Argentina v Uruguay Bet Builder Tip
Julian Alvarez to have 3+ shots
Federico Valverde to have 1+ shots on target
Enzo Fernandez to have 2+ shots
Pays 4.6/1
Julian Alvarez had three shots on goal in Argentina’s 4-0 thrashing of Bolivia at the start of August and the Atletico Madrid man will be expected to play an even more prominent role in the absence of Messi.
The 26-year-old has scored 16 international goals and has been in fine form for Atletico Madrid recently, registering 28 shots in his last 10 games for the club, and three or more shots in seven of those.
Teammate Enzo Fernandez is another who could threaten, with the Manchester City man having two pops on goal against Benin and regularly venturing forward for Argentina and City.
He had at least two shots in four of his World Cup appearances and has done the same in five of his last eight for the Citizens.
For Uruguay, much of their hope will rest on Real Madrid's Federico Valverde, who has scored in his last two club appearances.
Valverde has had at least one shot on target in four of his last five games and had 10 shots in three group-stage games at the World Cup.
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Key Match Stats
Argentina have won their last three games without conceding
Argentina have won to nil in four of their last five meetings with Uruguay
Julian Alvarez has had 28 shots in his last 10 games for Atletico Madrid
Enzo Fernandez has had two or more shots in five of his last eight appearances for his club
Nico Paz scored in all three of Argentina’s friendlies in September and October
The Como man has 18 combined goals and assists for club and country since the start of this season
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This article was written by a partner sports writer via Spotlight Sports Group. All odds displayed on this page were correct at the time of writing and are subject to withdrawal or change at any time.
