Liverpool's Premier League title hopes took a big blow with their 1-0 loss to Arsenal at the weekend, but they remain one of five teams to have won their opening three games in the UEFA Champions League.
They visit a Fenerbahce side who are in turmoil after sacking coach Domenico Tedesco, with former Reds forward Dirk Kuyt having taken interim charge of the Turkish giants.
Liverpool have made a solid start to life under Andoni Iraola, with their only two defeats coming against Manchester City and Arsenal.
The Reds have beaten Atletico Madrid, LASK and Villarreal in the UEFA Champions League and have scored 12 goals in the process.
They failed to have a shot on target in their weekend defeat to the Gunners, but could have been given a penalty and their opponents here are a significant drop in class from the Gunners.
There will be a familiar face in the dugout for Liverpool to face, with their former striker Kuyt taking over as interim Fener head coach following Tedesco's dismissal.
Fener are sixth in the Turkish Super Lig after losing four of their opening ten games and they are yet to win in the UEFA Champions League.
An opening 1-1 tie with Roma was positive, but they were beaten 6-0 away at Aston Villa after that and held to a 2-2 draw by Slavia Prague.
The home side have suffered three defeats in their last five games and after spending heavily in the summer, those performances were enough to see Tedesco depart.
Liverpool should be able to compound their misery with another away win, the Reds have won four in a row on their travels.
The hosts' squad is littered with former Premier League stars such as N'golo Kante, Romelu Lukaku and Nathan Ake, but there is a reason that they are no longer operating in the English top flight and Iraola's men can make the difference in levels clear.
Liverpool have scored at least three goals in four of their last five league phase matches in this competition and should be able to outscore their hosts.
However, both teams have scored in all three of the Reds’ UEFA Champions League games this season and looks likely again.
Bradley Barcola has been criticised since his move from Paris Saint-Germain to Liverpool and, while he has failed to make an impact in the Premier League, he has been better in the UEFA Champions League.
The slower pace of play and lower emphasis on physicality has made it easier for the Frenchman to acclimatise and Barcola scored a hat-trick against LASK as a result.
Against a Fenerbahce side who have already conceded nine goals in three of their league phase matches, expect Barcola to have another impressive performance and to find the net.
Former Leicester and Chelsea midfielder N’Golo Kante is widely regarded as one of the best midfielders in the world over the last 15 years, but he is not getting any younger and he could find himself vulnerable against this Liverpool team.
The 35-year-old has been booked three times already this season in all competitions and could struggle to keep the Reds midfield quiet, so take Kante for a card.
Read more betting picks and predictions for soccer on site.
Fenerbahce | +450 |
Tie | +375 |
Liverpool | -200 |
Alexander Isak (Liverpool) | -110 |
Lewis Koumas (Liverpool) | +100 |
Bradley Barcola (Liverpool) | +140 |
Cody Gakpo (Liverpool) | +140 |
Vedat Muriqi (Fenerbahce) | +200 |
Romelu Lukaku (Fenerbahce) | +210 |
Read the latest soccer news on site.
This article was written by a partner sports writer via Spotlight Sports Group. All odds displayed on this page were correct at the time of writing and are subject to withdrawal or change at any time.