Week 1 of the new College Football season continues on Sunday, with two highly anticipated games, one of which will see the #24 Louisville Cardinals, out of the ACC, take on the #9 Ole Miss Rebels, of the SEC.
This game between the Cardinals and Rebels is scheduled for7:30 PM ET and will be played at Nissan Stadium in Nashville, Tennessee.
Our article will preview this matchup between the Cardinals and Rebels by giving you our two best bets for the game, as well as the current betting odds.
Louisville vs. Ole Miss: Predictions, Player Props & Best Bets
Ole Miss Rebels -6.5 (-115)
Our top pick for this game will be for the Ole Miss Rebels to cover the spread.
The Rebels enter this game off a successful 2025-2026 season, finishing with a record of 13-2.
Ole Miss was able to advance to the College Football Playoff semifinals, but ultimately lost to the Miami Hurricanes by a score of 31-27.
They retain a number of star players this season, including their quarterback, Trinidad Chambliss, and their running back, Kewan Lacy.
Most notably, Lacy finished last season with 1,567 yards rushing (3rd most) and 24 touchdowns.
Further, Chambliss finished last season with 3,937 yards passing (3rd most), 22 passing touchdowns, and three interceptions.
As for Louisville, they finished the 2025-2026 season with a record of 9-4. The problem with the Cardinals is that they were not consistent enough last season.
Louisville started strong, but several key losses ultimately was their downfall, as they were not able to keep up in the ACC.
The Rebels are about a touchdown favorite, however, they still look to be the best betting option.
Last season, Ole Miss won their 13 games by an average margin of 19.2 points per game.
Louisville, on the other hand, lost their four games by an average margin of 9.8 points per game.
The returning firepower for Ole Miss, especially on the offensive side of the ball simply looks to be too much for this Louisville defense to handle.
For that reason, backing the Ole Miss Rebels to cover -6.5 will be our best bet.
Under 55.5 Total Points (-110)
Our second pick for this game will be targeting the under.
Last season, Ole Miss was one of the better offenses in the country, as they averaged 36.9 points per game. Defensively, Ole Miss was also solid, as they allowed 21.1 points per game.
Despite their mediocre finish to last season, Louisville also was an above average offensive team, as they averaged 29.9 points per game.
Their defense was also similar to the Rebels, as they allowed 21.2 points per game.
Overall, Louisville saw nine of their 13 games go under the total last season, while Ole Miss saw seven of their 15 games do the same.
Even though the Rebels were often in high-scoring games last season, the Cardinals are not a team that is likely to go score for score with them. For that reason, backing Under 55.5 Total Points will be our play.
Read more college football picks and predictions on site.
Louisville vs. Ole Miss Odds
Louisville Cardinals | +210 ML |
Ole Miss Rebels | -260 ML |
Spread | Louisville Cardinals +6.5 (-105) Ole Miss Rebels -6.5 (-115) |
Total Points | Over 55.5 (-110) Under 55.5 (-110) |
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This article was written by a partner sports writer via Spotlight Sports Group. All odds displayed on this page were correct at the time of writing and are subject to withdrawal or change at any time.
