Inter Miami and Atletico de San Luis kick off their 2026 Leagues Cup campaign in Florida this week and the two-time finalists, the Herons, are expected to get underway with a win.
Inter captain Lionel Messi returned to action off the bench in their weekend 2-2 draw with Columbus Crew in MLS, and he will be expected to play a more prominent role on Wednesday after a two-week break following the World Cup final.
Whether Messi starts or not, Vice City should still feel confident in its ability to beat a Liga MX side that has struggled in this tournament.
Inter Miami vs. Atletico de San Luis betting picks and predictions
Inter Miami over 2.5 team goals (-110)
Inter Miami may have been held to a draw at home to Columbus Crew at the weekend, but their scoring talents were still on display as they put two past the visitors.
They now look set to begin their quest for a second Leagues Cup triumph against Atletico de San Luis.
The visitors have conceded 12 goals in their last three opening games in this competition and five in their last three matches.
The Herons, who have scored 13 goals in their recent four-game unbeaten run at home, have a star-studded attacking lineup and have reached the Leagues Cup final in two of the past three years.
With Messi likely to return to the fray and Casemiro bedding in at his new club, Inter Miami has a legendary setup and can get at least three goals against underdogs Atletico.
Inter Miami to win & both teams to score (+140)
Inter Miami has won six of its seven meetings with Mexican opposition in the Leagues Cup, and there is little to suggest that Atletico de San Luis can stop them in Florida this week.
The Herons have never lost a home Leagues Cup game and face a Mexican side that has lost their last three openers in this competition.
Atletico are winless in their last three in all competitions, but they have scored four goals in this period and do have an attacking edge that can put Vice City under pressure.
Inter Miami have conceded eight times in their last four games, keeping just one clean sheet, so backing the Mexicans to grab a consolation at Nu Stadium is sensible.
Luis Suarez to score anytime (-120)
Luis Suarez stepped up in Lionel Messi's absence and was once again the star in the draw with the Columbus Crew.
The former Liverpool and Barcelona man ended a two-game goalless streak by bagging a hat-trick against Philadelphia Union in May and has since scored seven goals in his last four appearances.
The Uruguayan has not failed to find the net in any of those games, and he is worth taking on to continue his scoring streak.
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Inter Miami vs Columbus Crew odds
Inter Miami | -250 |
Tie | +400 |
Atletico de San Luis | +550 |
Inter Miami vs Columbus Crew player props
Anytime Goalscorer
Lionel Messi (Inter Miami) | -275 |
Luis Suarez (Inter Miami) | -120 |
German Berterame (Inter Miami) | -120 |
Daniel Pinter (Inter Miami) | +120 |
Joao Pedro (Atletico de San Luis) | +160 |
Mateo Silvetti (Inter Miami) | +175 |
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This article was written by a partner sports writer via Spotlight Sports Group. All odds displayed on this page were correct at the time of writing and are subject to withdrawal or change at any time.
