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Colts vs. Chiefs: Betting Odds & Preview for Sunday Night Football

After a disappointing 2025 season, the Kansas City Chiefs look to get off to a hot 2-0 start in 2026 when they host the Indianapolis Colts in primetime on Sunday.

Game

Indianapolis Colts vs. Kansas City Chiefs

Date

Sunday, September 20

Kickoff Time

8:15 p.m. ET / 7:15 p.m. CT

Stadium

Arrowhead Stadium, Kansas City, MO

TV Channel

NBC

The Indianapolis Colts were tormented by a dominant rushing offense in Week 1 against the Baltimore Ravens, and they'll face another run-heavy team Sunday night.

Kenneth Walker III and the Kansas City Chiefs ran all over the Denver Broncos during the NFL's inaugural Monday Night Football game last week in what looks to be a new offensive philosophy for the team.

KC signed last year's Super Bowl MVP in free agency and promptly gave him 23 carries on Monday. He rushed for 173 yards, broke nearly 15 tackles, and scored twice. Overall, the Chiefs ran for 220 yards - slightly more than the 202 yards the Colts gave up on the ground to Derrick Henry and co.

We'll see if Indy can slow down the new-look Chiefs in primetime. Below is a look at the odds for potential touchdown scorers in the game, with odds provided by bet365.

Colts vs. Chiefs Betting Odds

All odds written in this article were correct at the time of writing and are subject to change.

Spread, Total, Moneyline

Spread

Total

Money

IND Colts

+6.5 -105

O 46.5 -110

+240

KC Chiefs

-6.5 -115

U 46.5 -110

-300

Odds presented by bet365

Touchdown Scorer Odds

Player

Anytime TD

First TD

Kenneth Walker III

-205

+270

Jonathan Taylor

-140

+350

Rashee Rice

+130

+650

Travis Kelce

+180

+900

Tyler Warren

+250

+1250

Xavier Worthy

+245

+1250

Alec Pierce

+350

+1800

Josh Downs

+375

+1800

Patrick Mahomes

+350

+1800

Keenan Allen

+390

+2000

Emmett Johnson

+425

+2200

Tyquan Thornton

+575

+2800

Daniel Jones

+625

+3000

Kenneth Walker III Rushing Props

Over

Under

79.5 Rushing Yards

-115

-115

18.5 Rushing Attempts

-120

-110

16.5 Yard Longest Rush

-120

-110

100+ Rushing Yards

+200

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