Check out the latest news and information on Tottenham's ongoing injury crisis after Sandro Tonali became the latest player to be sidelined.
It has been a dismal start to the season for Spurs under Roberto De Zerbi, despite a free-spending summer in the transfer market that saw a number of high-profile arrivals in North London.
A goalless draw with Everton on Saturday saw the club's winless start to the campaign continue, and they currently sit 17th in the table with just two points from four games.
Tottenham are one of just two teams that are yet to score a goal in the Premier League, and there are fears that the club could once again find itself battling relegation despite the astronomical scale of the investment in the playing squad.
To make matters worse, injuries have already began to rear their head, an issue that has consistently plagued the club in recent years.
Ahead of their EFL Cup clash with Liverpool Spurs had no fewer than nine senior players sidelined with injury, with De Zerbi forced to adapt his selections accordingly.
As Tottenham face yet another injury crisis, we've taken a look at the timelines for all players currently unavailable.
Just weeks after becoming the most expensive player in Tottenham's history Sandro Tonali now finds himself on the club's seemingly ever-expanding injury list.
The Italian has featured in all four Premier League games for the club this season but will not feature in their EFL Cup opener at Anfield.
However, Tottenham fans can breathe a sigh of relief as De Zerbi was quick to insist that it just a minor knock has seen him ruled out, and that he should be back in contention in time for the club's clash with Aston Villa on Saturday.
It's not all bad news for Tottenham on the injury front.
While the club will be without a number of key players for the trip to Anfield it appears that Destiny Udogie will be in line to feature.
The full-back missed their 0-0 draw with Everton at the weekend with a minor issue but has recovered in time for the midweek fixture.
One of the longest-serving players at the Tottenham Hotspur Stadium, Pedro Porro is an integral part of De Zerbi's plans but has not featured regularly for the club this season.
After featuring in Spain's victorious World Cup campaign this summer Porro's minutes have been managed since his return, with an ongoing muscular issue leading to De Zerbi being particularly cautious.
While the full-back has been ruled out of the Liverpool fixture, he should be back in contention when Spurs play host to Villa at the weekend.
It's been a difficult 18 months for James Maddison. After missing almost the entirety of last season through an ACL injury Maddison made his return before the end of the campaign as Spurs narrowly retained their top-flight status.
Maddison has again found consistent minutes hard to come by this season due to a shoulder injury that saw him miss both the defeat by Newcastle and the draw with Nottingham Forest earlier this month.
The midfielder returned in the closing stages against Everton and De Zerbi insisted after the game that he will continue to manage his minutes as he progresses in his recovery.
Another of Tottenham's summer arrivals to have since found himself on the treatment table, Mykhailo Mudryk is set for a spell on the sidelines after sustaining an ankle injury in training.
Mudryk made his long-awaited return to football in Spurs' draw with Forest earlier this month but now faces a lengthy wait before getting back on the pitch.
The Ukrainian now faces several weeks out of action, with Tottenham's clash with Coventry City on October 19 reportedly viewed as a tentative return date.
One of Spurs' long-term absentees, Wilson Odobert suffered a ruptured ACL in the club's clash with Newcastle back in February.
After undergoing successful surgery the French forward has undergone an extensive rehabilitation program but is still some way away from returning to action.
Asked for an update recently De Zerbi revealed that Odobert will not feature in 2026, with a March return a possibility.
Like Odobert, Xavi Simons also faces an extended spell away from the pitch after an injury to his anterior cruciate ligament.
There were some hopes that Simons could be back in time to feature early in the new year but the prognosis is now decidedly less optimistic.
In a recent interview the Spurs boss intimated that the Dutchman may not be ready to return until the final months of the season.
After the departures of Harry Kane and Son Heung-min, Dejan Kulusevski appeared poised to become Tottenham's latest talisman having been a revelation after finding his feet in English football.
16 months have passed since Kulusevski last played a competitive fixture, though hopes have been raised recently that he could soon make his long-awaited return.
After training alongside his team-mates earlier this month the Swede suffered a minor setback and is once again training away from the squad with a date for a potential return to action currently unknown.