After top seed Aryna Sabalenka's fourth-round exit, world number four Jessica Pegula is the highest-ranked player left in the women's draw at Wimbledon, as she prepares herself for an all-American quarter-final with Coco Gauff.
One certainty is that Wimbledon will crown a new women's singles champion, and both Pegula and Gauff will believe they have what it takes to make the next step.
Pegula recorded straight-sets victories over Darja Vidmanova, Sara Sorribes and Jessica Bouzas Maneiro in her first three assignments before battling from a set down to see off up-and-coming youngster Iva Jovic in the last 16.
Gauff has had to work much harder to make the quarter-final, needing three sets to overcome Solana Sierra, Claire Liu and Belinda Bencic in her last three matches.
That makes for an intriguing quarter-final duel and both players are bidding to break new ground and make the last four at the All England Club for the first time.
Best Bet - Jessica Pegula to win the match @ 8/11
Alternative Bet - Jessica Pegula to win first set @ 4/5
Bet Builder - Jessica Pegula to win 2-0, 5+ aces for Coco Gauff & 8+ double faults for Coco Gauff @ 14/1
Best Bet - Jessica Pegula to win the match @ 8/11
These are two of the best in the world and they have an intense rivalry, with Pegula narrowly leading their personal series 5-4.
There has been nothing straightforward about Gauff's run to her first Wimbledon quarter-final. She needed a deciding set tiebreak to see off Sierra in round two before also being taken the distance by Liu in her third-round encounter.
In round four, Gauff lost the opening set to Bencic before roaring back and it may be that Pegula is performing to a higher standard.
Pegula has yet to secure a Grand Slam title but she should see this as her chance, with Sabalenka, Iga Swiatek and Elena Rybakina all out and it is an opportunity she cannot afford to let pass her by.
Gauff can struggle with her serve, and she made nine double faults against Bencic, which will make this an uphill battle against Pegula in such strong touch.
The fourth seed has dropped just one set on her way to the quarter-final and she won 7-5 7-6 in her last grass-court meeting with Gauff in Berlin two years ago.
Alternative Bet - Jessica Pegula to win first set @ 4/5
Gauff lost the opening set to Bencic in the fourth round, despite racing into an early 3-0 lead, and she tends to come on strongly in matches so a fast start is imperative for Pegula.
Gauff can take time to warm to the task, with her serving often putting her under unnecessary pressure, and Pegula has won four of her last six meetings with her compatriot.
The fact that Gauff has played a deciding set in her last three matches shows that she may not be at her absolute peak.
Pegula will demand a strong start, as she knows how dangerous her fellow American can be when it's crunch time.
Jessica Pegula to win 2-0
5+ aces for Coco Gauff
8+ double faults for Coco Gauff
Pays 14/1
Gauff has needed a deciding set in her last three victories and she could be punished by Pegula.
Gauff's serve can blow hot and cold. When she finds her first serve, she can rack up the aces, otherwise plenty of double faults tend to fall her way.
The American had eight aces and 17 double faults in a three-set defeat in her last meeting with Pegula and this Wimbledon quarter-final could follow a similar pattern.
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Pegula has won four of her last six meetings with Gauff.
Pegula has won seven of her last eight matches.
Five of Gauff's last six matches have gone to a deciding set.
Gauff had lost four straight grass-court matches before enjoying a four-match winning streak at Wimbledon.
Three of Pegula's four Wimbledon wins have ended 2-0.
Pegula has made the semi-final in two of her last three Grand Slam appearances.
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This article was written by a partner sports writer via Spotlight Sports Group. All odds displayed on this page were correct at the time of writing and are subject to withdrawal or change at any time.