Olympiacos will be hoping to make up some ground on a Panathinaikos side that are already pulling away from the chasing pack in the Greek Super League when they face off on Sunday.
The visitors have won all five of their games so far, scoring twelve and conceding just two.
New manager Jacob Neestrup has got them off to a dream start, sitting three points clear at the top with a goal difference only matched by AEK Athens.
Hosts Olympiacos are already five points behind and occupy fifth in the division having won three, drawn one and lost one.
They have found some momentum since losing to OFI though, beating Jagiellonia Bialystok in the Europa League and following it up with a 0-1 win at Levadiakos.
How to watch Olympiacos v Panathinaikos, live stream and TV channel
Olympiacos v Panathinaikos is being live streamed in the UK via the bet365 Live Sports Streaming service.
The fixture isn't being shown on TV anywhere in the UK.
Olympiacos v Panathinaikos kick-off time, date and venue
Olympiacos v Panathinaikos will be played at Georgios Karaiskakis Stadium in Piraeus, Greece and kick-off is at 19:00 (BST) on Sunday 11th October.
