Toronto hosts the second game in Group L this evening, where Ghana take on Panama in a vital fixture for both sides.
Drawn alongside group favourites England and 2022 semi-finalists Croatia, Group L looks a tough ask for both Ghana and Panama and securing third place may prove to be their best chance of qualification.
With that in mind, both sides will have identified tonight's fixture as a key match in their World Cup ambitions this summer, and an intriguing battle is sure to unfold at the Toronto Stadium.
In a match of fine margins, the tie may be won by an individual moment of magic from either side. Here we analyse potential contenders to stamp their mark on proceedings in Canada and be named Player of the Match.
Despite displaying some questionable form heading to North America this summer, Ghana are the favourites to prevail in tonight's meeting with Panama.
The Player of the Match market is reflective of the Black Stars favouritism, with three of the top four players in the betting representing Ghana.
Manchester City star Antoine Semenyo is the favourite to be given the award in Toronto, the 26-year-old has developed into one of the brightest talents in the Premier League in the last couple of seasons and stands out as an obvious key man for the Black Stars this summer.
Another name prominent in the betting that will be familiar to fans of English football is Ghana captain Jordan Ayew, who is the joint-record appearance maker for his nation, alongside older brother Andre.
Ayew has turned out for several clubs across England during his long career, and his record of 34 goals in 120 matches for Ghana suggests he will be another vital asset in their World Cup campaign.
The first Panamanian player in the odds is left winger Ismael Diaz, who turns out for Mexican outfit Club Leon.
Diaz has scored 17 goals in 56 appearances for Panama and is sure to play a key role for his nation this summer; the 29-year-old netted twice in six games during qualification.
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