Crystal Palace rediscovered their goalscoring touch with a 3-1 win over Nottingham Forest on Sunday and the Eagles will be confident they can take another step forward in the Europa League after beating Polish side Lech Poznan 4-0 in their league-phase opener.
However, while Lyon fell to a 2-1 defeat to Lens in Ligue 1 at the weekend, the French side have a strong home record in the Europa League and demonstrated in their previous win over Anderlecht that they will not be a pushover, particularly on their own patch.
Best Bet - Lyon to win @ 13/10
Alternative Bet - Ernest Nuamah to score at any time @ 9/4
Bet Builder - Over 2.5 goals, Jorgen Strand Larsen to have 3+ shots & Corentin Tolisso to have 1+ shot on target @ 7/2
Best Bet: Lyon to win @ 13/10
Palace have overcome a sticky start to life under new manager Pierre Sage, with 15 goals in their last six games, but there is still potential for them to come unstuck at Lyon on Thursday.
The Eagles celebrated a Conference League triumph last season, but they face a team with extensive experience at this level who could just hold the edge on the night.
The hosts fell to a 2-1 defeat against Lens at the weekend, but that ended a run of five unbeaten games and they have scored seven goals in their last two home Ligue 1 outings.
A 2-1 victory at Anderlecht in their opening clash is another cause for optimism and it seems prudent to respect a team who have won seven of their last eight league-phase games in this competition.
Alternative Bet: Ernest Nuamah to score at any time @ 9/4
Lyon striker Ernest Nuamah was on target twice when his team saw off Rennes 4-0 in their last home game and he looks geared to repeat the trick on Thursday.
He had four shots on target on that occasion and his confidence should have been further boosted by a goal for Ghana against Gambia in a recent Africa Cup of Nations qualifier.
Having missed the last Europa League game against Anderlecht, he should be keen to make his mark as Lyon look to build upon the win they claimed in Belgium.
Over 2.5 goals
Jorgen Strand Larsen to have 3+ shots
Corentin Tolisso to have 1+ shot on target
Pays 7/2
Seven of Lyon's 11 games this season have featured at least three goals, including each of their last three, and there looks to be a strong chance that that run can be extended.
Palace drew 0-0 at Leeds United the last time they were on the road, but over 2.5 goals has been a winning bet in the other six of their last seven games.
Their striker Jorgen Strand Larsen looks set to continue to lead the line and he could have at least three shots in Thursday's encounter.
This has happened in three of his last four appearances for the Eagles, a run that included five attempts in the 4-0 win over Lech Poznan when he scored from the penalty spot.
It is also worth backing Lyon captain Corentin Tolisso to have a shot on target.
The versatile midfielder has been playing in an attacking role lately and has had ten shots on target in his 11 appearances this term, so it would not be a shock if he tested the Palace goalkeeper at least once.
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Both teams have scored in five of Lyon's last seven matches
All three of Lyon's defeats this season have been by a 2-1 scoreline
Crystal Palace have won four of their last six games
There have been at least four goals in five of Palace's last seven outings
The Eagles have failed to score in just one of their last 14 European matches
Lyon have won seven of their last eight league phase games in the Europa League
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This article was written by a partner sports writer via Spotlight Sports Group. All odds displayed on this page were correct at the time of writing and are subject to withdrawal or change at any time.