Former AC Milan hero Gennaro Gattuso will be looking to down the club he starred for and make it a perfect four wins from four in Serie A for new side Lazio.
Gattuso has overseen Biancocelesti wins against Bologna, Genoa and Udinese in Serie A, but this is a different test altogether.
Milan, also unbeaten, won their first two games against Torino and Venezia before hanging on for a 1-1 draw at Juventus last weekend.
Best Bet - Draw @ 9/4
Alternative Bet - Koni De Winter 2+ tackles @ 11/10
Bet Builder - Alphadjo Cisse over 0.5 shots on target, Over 10.5 Lazio shots, Oliver Provstgaard to be booked @ 10/1
Best Bet: Draw @ 9/4
The Stadio Olimpico hosts unbeaten duo Lazio and Milan and the sensible option is surely to presume they will both still be unbeaten after 90 minutes.
The home side have won three out of three, a pinch-me stat for Lazio fans given they started their campaign - and Gattuso's reign - with a timid 2-0 home Coppa Italia exit to Serie B Mantova.
They haven't yet played a top-four contender such as Milan, who saw off Torino (2-1) and Venezia (2-0) in their first two games before drawing 1-1 at Juve.
They were minutes away from holding on for victory, though Juve were far the better team overall.
Ruben Amorim is trying to rebuild the Rossoneri his way, which means tweaks and tactical stubbornness, a storyline familiar to Manchester United fans.
Neither side was great last season and neither looks special right now, so a tight contest of few chances which ends all square would surprise no one.
Alternative Bet - Koni De Winter 2+ tackles @ 11/10
Milan's Belgian ace Koni De Winter was the absolute superstar at the back for his team at the Allianz Stadium last week.
As Juve piled on the pressure, De Winter stood firm with a game-high nine clearances and five tackles attempted.
De Winter got booked for his troubles and has now successfully made seven tackles this season. He looks a good bet at a nice price to make two or more in Rome.
Alphadjo Cisse over 0.5 shots on target
Over 10.5 Lazio shots
Oliver Provstgaard to be booked
Pays 10/1
Milan only came to life when Alphadjo Cisse and Samuel Chukwueze came off the bench in Turin a week ago.
Cisse, the club's 19-year-old superstar, had started Milan's first two games, scoring against Torino before he found the net in the second half at Juve despite feeding off scraps.
You would expect Amorim to start Cisse at Lazio and be more proactive, which could mean the youngster has at least one effort on target.
Lazio have recorded 10, 15 and 19 shots in their three games and, at home, against a modest Milan, can definitely reach 11 shots over 90 minutes as a minimum.
With seven fouls in three games and a yellow card already received against Bologna, Lazio's Oliver Provstgaard looks like a prime candidate for a caution.
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Lazio have kicked off the season with three straight wins, making them one of three teams on nine points
AC Milan kicked off their season with a 2-1 win at Torino and 2-0 win over Venezia before drawing 1-1 at Juventus
Lazio midfielder Davide Frattesi has scored in each of his side's three games so far
All five Milan goals this season have been scored in the 64th minute or later and there has not been a single first-half goal in their three fixtures
There have been 17 yellow cards shown in Lazio's three Serie A games so far this season
Under 8.5 corners has come in in each of Milan's three league matches this term
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This article was written by a partner sports writer via Spotlight Sports Group. All odds displayed on this page were correct at the time of writing and are subject to withdrawal or change at any time.