Inter Miami beat Mexican side Cruz Azul 2-0 to lift the Campeones Cup in their last game but Inter's focus switches back to MLS on Monday.
Lionel Messi, who scored the opening goal against Cruz Azul, and his Inter teammates return to league action as hot favourites to beat San Diego FC in Miami.
Best Bet - Inter Miami to win & both teams to score @ 21/20
Alternative Bet - San Diego FC to be shown most cards @ 7/4
Bet Builder - Over 2.5 goals, Anders Dreyer to score or assist & Kieran Sargeant to be booked @ 7/1
Best Bet: Inter Miami to win & both teams to score @ 21/20
Inter Miami have had a frustrating run of results in MLS, winning only one of their last eight matches.
Five of those games ended in draws but Inter's only win was by a comprehensive margin as they hammered Montreal 7-1 at the end of August.
Lionel Messi scored four times in that rout, with Casemiro and Luis Suarez also on the scoresheet, and Inter's attacking stars should be too slick for San Diego FC.
This is the first MLS meeting between the teams and San Diego arrive in Florida at a low ebb.
They have lost their last three matches, conceding 10 goals, and have struggled on the road this season.
San Diego's six away defeats include a 3-1 loss at Portland and a 4-2 reverse at Real Salt Lake so Inter to win and both teams to score is a good bet.
There have been goals at both ends in 11 of Inter's 12 home fixtures this season and their last three wins on their own patch were by 6-4, 3-2 and 7-1 scorelines.
San Diego are expected to be missing injured top scorer Marcus Ingvartsen, who has found the net 11 times in MLS this season.
However, the outstanding Anders Dreyer can help the visitors get on the scoresheet in a high-scoring defeat in Miami.
Alternative Bet: San Diego FC to be shown most cards @ 7/4
A lack of discipline has hampered San Diego FC this season and they look a big price to receive the most cards in Monday's game.
They have picked up eight red cards in 25 MLS matches and had three players sent off in March's CONCACAF Champions League last-16 tie against Toluca.
Oscar Verhoeven is suspended for the trip to Miami but goalkeeper CJ Dos Santos returns from a ban after his dismissal for two bookable offences against San Jose Earthquakes.
San Diego's midfielders and defenders should be put under massive pressure from a star-studded Inter side and that could lead to some rash challenges from the visitors.
Over 2.5 goals
Anders Dreyer to score or assist
Kieran Sargeant to be booked
Pays 7/1
Over 2.5 goals looks a solid Bet Builder selection. Inter Miami's MLS home fixtures this season average 4.75 goals per game and San Diego lost their last two matches 3-2 and 5-0.
San Diego's Danish winger Anders Dreyer poses a threat to the home defence, having racked up nine goals and 10 assists in his 23 league starts this season.
Left-back Kieran Sargeant will have the dubious honour of marking Inter star Lionel Messi and the San Diego defender was booked in his last away game at Orlando City.
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This article was written by a partner sports writer via Spotlight Sports Group. All odds displayed on this page were correct at the time of writing and are subject to withdrawal or change at any time.