Australia have already lost their ODI series in South Africa and face a huge task when trying to salvage some pride in the third and final match in Potchefstroom on Wednesday.
The Baggy Green will definitely be without pacer Nathan Ellis due to a side strain, while Jack Edwards is a major doubt because of a hamstring problem and fellow all-rounder Cameron Green (shoulder) is still unable to bowl.
That means that Pat Cummins is almost certain to make his first appearance of the series, with Mitchell Starc also set to return, while Josh Hazlewood is set to be rested after playing in the opening two defeats.
Best Bet - South Africa to win @ 2.00
Alternative Bet - Matthew Breetzke top South Africa batter @ 4.75
Bet Builder - Most sixes - Australia, Highest opening partnership - Australia & Keshav Maharaj top South Africa bowler @ 11.00
Best Bet: South Africa to win @ 2.00
The match result market sees the two teams as very evenly matched, but the series so far has been dominated by the Proteas, as they won by 67 runs at Kingsmead and 33 runs in a high-scoring encounter at The Wanderers.
A look at the longer-term trends suggests that there is even more reason to go with the hosts to complete a series sweep, as South Africa have won eight of their last 10 one-day internationals against Australia.
Their dominance on home soil is even more profound as the Baggy Green have lost 13 of the last 15 one-dayers they have played in South Africa, with injuries among their bowlers making their task on Wednesday even more daunting.
Alternative Bet: Matthew Breetzke top South Africa batter @ 4.75
Matthew Breetzke made his lowest ODI score against Australia in the 33-run victory in Johannesburg, as David Miller took centre stage with an amazing knock of 142 from just 94 balls faced, even upstaging a century from skipper Temba Bavuma.
However, that Breetzke knock can hardly be described as a failure, as he made 34, even if his previous scores against the Aussies in ODI cricket are 57, 88 and 112.
The 27-year-old right-hander has passed 50 in eight of his 15 ODI innings to date and he can lead the way for the Proteas once again as the hosts chase a 3-0 series whitewash.
Most sixes - Australia
Highest opening partnership - Australia
Keshav Maharaj top South Africa bowler
Pays @ 11.00
Even if South Africa are taken to win the match at Senwes Park in Potchefstroom, Australia can lead the way in both the match sixes and top opening partnership markets.
The Aussies lost the sixes count 8-7 in the series opener, before being outhit 15-12 in the second ODI, with the outcome at The Wanderers being heavily skewed by Miller smashing nine maximums in his outstanding innings.
They can respond in the series finale and lead the way, with Mitch Marsh a major factor as he has hit 25 sixes in his last nine ODI innings, while Marsh can also help Australia have the top opening partnership.
He and Travis Head put on 90 and 130 for the first wicket in the defeats in Durban and Joburg, way ahead of South Africa's marks of 6 and 0.
Finally, left-arm spinner Keshav Maharaj is added to lead the way with the ball for the home side, having taken six wickets in the series to date, taking his tally to 24 wickets in 14 ODI matches against Australia.
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South Africa have won eight of their last 10 ODIs against Australia
The Proteas are unbeaten in the three previous ODIs between these two sides in Potchefstroom
David Miller has scored two centuries in his last three ODI innings
Australia have lost 13 of the last 15 one-dayers they have played in South Africa
Pat Cummins has taken nine wickets in five previous ODIs in South Africa
Mitch Marsh has hit 25 sixes in his last nine ODI innings
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This article was written by a partner sports writer via Spotlight Sports Group. All odds displayed on this page were correct at the time of writing and are subject to withdrawal or change at any time.