Mikel Arteta takes his side on a trip to the North West coast where they will face League Two outfit Fleetwood Town in the fourth round of the EFL Cup.
Runners-up last season, the Gunners charted safe passage through to this round courtesy of a 4-2 victory over Ipswich at Portman Road.
There are 84 places separating the two clubs in the English Football pyramid; Arsenal second in the Premier League and Fleetwood 18th in the fourth tier. The visitors have lost just once this season, winning 11 of their 13 games in all competitions and are long odds-on 1/12 favourites to get the job done in 90 minutes at the Emirates.
With a trip to Anfield coming up in five days time, Arteta is expected to make wholesale changes to the side that beat Everton 2-0 last time out.
First of all three-time Golden Glove winner David Raya is expected to make way between the sticks for former Leeds shot-stopper Illan Meslier.
Ben White may retain his place at right-back, but the rest of the defence could take on a completely different look, with Marli Salmon potentially in line to start alongside Cristhian Mosquera and Piero Hincapie.
England international Declan Rice and Norway captain Martin Odegaard are both expected to drop to the bench, making way for Martin Zubimendi and Bruno Guimaraes to slot into the midfield with Mikel Merino.
Eberechi Eze could start on the left side of attack, Viktor Gyokeres through the middle, leaving space for Max Dowman to feature off the right.
Arsenal predicted lineup
Illan Meslier; Ben White, Marli Salmon, Cristhian Mosquera, Piero Hincapie; Martin Zubimendi, Mikel Merino, Bruno Guimaraes; Max Dowman, Viktor Gyokeres, Eberechi Eze
Any odds displayed were correct at the time of writing and are subject to fluctuation.
