Sloane Stephens is the last American tennis player to win the US Open with her breakthrough victory in 2017, but there will be a number of home hopefuls that will believe they can follow in her footsteps.
Stephens became the first American woman other than Venus and Serena Williams to win the American major since Jennifer Capriati lifted the title in 2002.
The last American man to triumph at the US Open was Andy Roddick, who claimed his one and only Grand Slam title on home soil in 2003.
That came hot on the heels of Pete Sampras's victory in 2002, which was the Californian's 14th Grand Slam win and his fifth in total in his home Slam.
|What||2023 US Open|
|Where||USTA Billie Jean King National Tennis Center, Flushing Meadows, New York|
|When||Monday, August 25th - Sunday September, 10th|
Men: Novak Djokovic +120, Carlos Alcaraz +175, Daniil Medvedev +900
Women: Iga Swiatek +240, Aryna Sabalenka +500, Coco Guaff +650
With 23-time Grand Slam champion Serena Williams having recently retired, Americans are crying out for a new tennis superstar.
And there is every chance they may have found one in Cori Gauff who, at only 19 years of age, has plenty of time on her side.
Despite her tender years, Gauff is fairly experienced having already been a professional on the WTA Tour for four seasons.
The teenage star is a four-time title winner and she will arrive at the US Open full of confidence having made the final on her most recent tournament start in similar conditions in Cincinnati.
Gauff defeated world number one Iga Swiatek in her semifinal encounter and is already a Grand Slam runner-up having played second fiddle to the Pole at the 2021 French Open.
The Georgian native was a quarterfinalist at the US Open last year and it shouldn't be long until she makes her breakthrough at the top table.
The athletic American, who is already at world number seven and has the world at her feet, is +650 to triumph at Flushing Meadows in September.
Taylor Fritz is the highest-ranked American male player at world number nine and he certainly has a game that is to be feared at the US Open.
The hard-hitting Fritz possesses a serve that makes him a threat to all and his recent form has been encouraging.
Last time out, the 25-year-old made the quarterfinal in Cincinnati, where he was unfortunate to bump into a determined Novak Djokovic.
However, that highlights the consistency of Fritz, who had won a hard-court title in Atlanta at the end of July before finishing runner-up in Washington.
These conditions play to the strengths of the Californian, who is a Grand Slam quarterfinalist, having made the final eight at Wimbledon in 2022.
A bit of luck with the draw and Fritz could outrun his outright odds of +4000.
On the back of a hard, gruelling season, the US Open can throw up some surprise results and that was highlighted last year.
Although world number one Carlos Alcaraz was a worthy winner, the other three semifinalists were made up of Karen Khachanov, Casper Ruud and Frances Tiafoe.
So Tiafoe knows he performs well under the conditions of his home Grand Slam and the 25-year-old would be a lively outsider again.
Tiafoe has not looked back since making the last four at Flushing Meadows and is now at a career-high ranking of world number 10, so can't be ruled out at +5000.
At world number three, Jessica Pegula is the highest-ranked American female and she will head to Flushing Meadows as one of the leading title contenders.
However, for all of her consistency, the 29-year-old has a habit of coming up short in the showpiece events.
Pegula has made six Grand Slam quarterfinals from her last 11 appearances, yet has never gone beyond the last eight in her career.
So while the American is likely to go deep, she may struggle to land the odds at +850.
Danielle Collins and Jennifer Brady are two other impressive American women but the resurgent Madison Keys may have stronger credentials than that pair.
Keys was runner-up to Sloane Stephens at the US Open in 2017 and she went on to make the final four a year later.
After a quiet couple of seasons, which were plagued with injury, Keys went on to make the Wimbledon quarter-final earlier this summer.
At +4000, there could be worse outsiders to pin your hopes on.