Real Madrid vs. Arsenal: Picks, Predictions, Odds and Player Props

Real Madrid is the most successful club in UEFA Champions League history but the Spanish giants need to stage an amazing comeback in order to reach this season's semifinals.

Los Blancos lost 3-0 at Arsenal in the first leg of their quarterfinal tie, and the Gunners are aiming to produce another memorable performance at the Estadio Santiago Bernabéu.

Mikel Arteta's men know they still have plenty of work to do to seal a semifinal spot and eliminate a Real Madrid side featuring plenty of stars, including Kylian Mbappe, Jude Bellingham and Vinicius Jr. 

Real Madrid vs. Arsenal betting picks and predictions

Tie (+333)

Arsenal's hopes of catching Premier League leaders Liverpool have been undermined by four ties in their last six matches.

However, Gunners fans would be delighted with another stalemate in the second leg of their UEFA Champions League quarterfinal against Real Madrid, having beaten the Spanish champions 3-0 in north London last week.

Real is renowned for its UEFA Champions League exploits, lifting the trophy on a record 15 occasions.

Carlo Ancelotti's men have conjured up some amazing comebacks in recent European ties, but their confidence must have been shaken by the manner of their first-leg defeat.

A couple of stunning free kicks from Declan Rice helped Arsenal take control of the game. The hosts could have won by an even wider margin but for some great saves from Real Madrid goalkeeper Thibaut Courtois.

The emphasis is on defense rather than attack for Arsenal manager Mikel Arteta in Madrid, and he has made the Gunners tough to beat. Arsenal is unbeaten in 20 Premier League meetings with traditional 'big six' rivals Manchester City, Liverpool, Manchester United, Chelsea and Tottenham.

The Gunners conceded only six goals in 11 UEFA Champions League matches this season and two of those came in the last-16 second leg against PSV, who had been thrashed 7-1 in the first leg in Eindhoven.

Real Madrid has lost five of its last 10 league and cup matches in 90 minutes, winning the other five by a one-goal margin, and Arsenal's defense is capable of shutting down any chance of a fightback from the holders.

Kylian Mbappe Over 2.5 Shots on Target (+175)

Real Madrid striker Kylian Mbappe is the obvious danger to Arsenal in the second leg and the France star can rack up Over 2.5 shots on target.

Even though Real was outplayed in London, Mbappe had three shots, two of which forced Arsenal 'keeper David Raya into a save.

The forward will be determined to make up for his first-half red card in Real's 1-0 league win at Alaves at the weekend.

He had 15 shots in his last two home fixtures against Leganes and Villarreal and has scored 22 goals in 29 La Liga appearances in his first season in Spain.

Mbappe claimed a hat-trick in February's UEFA Champions League playoff second leg against Manchester City, amassing 12 shots in the two-legged tie, and he can ensure that Raya has a busy night in the Arsenal goal. 

Jurrien Timber to be booked (+300)

Arsenal right-back Jurrien Timber was an injury doubt for the first leg but he proved his fitness and character with a heroic display against Mbappe and Vinicius Jr.

Timber made four tackles in the home leg and the only player to exceed that tally was Real midfielder Eduardo Camavinga, who was sent off for a second yellow card.

The Gunners' Dutch defender can expect another testing 90 minutes against Real, especially as left-back David Alaba loves to get forward and join in attacks.

Before the first leg, Timber had been booked in his previous two UEFA Champions League starts, against Dinamo Zagreb and PSV, and he has collected seven yellow cards in this season's Premier League – two more than any other Arsenal player.

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Real Madrid vs. Arsenal odds

Real Madrid	-143
Tie	+333
Arsenal	+333

Real Madrid vs. Arsenal player props

Anytime Goalscorer

Kylian Mbappe (Real Madrid)	+100
Vinicius Jr. (Real Madrid)	+175
Endrick (Real Madrid)	+175
Arda Guler (Real Madrid)	+187
Jude Bellingham (Real Madrid)	+187
Rodrygo (Real Madrid)	+250
Brahim Diaz (Real Madrid)	+300
Bukayo Saka (Arsenal)	+300

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This article was written by a partner sports writer via Spotlight Sports Group. All odds displayed on this page were correct at the time of writing and are subject to withdrawal or change at any time.