Paraguay and Uruguay both sit comfortably in the top six of CONMEBOL World Cup qualifying and are expected to confirm their places in next summer's World Cup, but nothing is set in stone as of yet.
Each side sits on 21 points from 14 qualification matches, with Uruguay two places ahead due to their +7 goal difference, compared to Paraguay's +3.
Paraguay have been in fine form in qualifying, going eight matches unbeaten including wins against Argentina and Brazil.
Uruguay have scored just four goals in their last eight qualifying matches, three of which came in one game vs. Colombia, but have been just fine thanks to a sturdy defense that conceded just five goals over that span.
Let's get into what you need to know ahead of Thursday's match.
Paraguay vs. Uruguay will be shown on Fanatiz USA for viewers in the United States.
Paraguay vs. Uruguay will kick off at 7 PM ET / 6 PM CT / 4 PM PT on Thursday, June 5 from Estadio ueno Defensores del Chaco in Asuncion, Paraguay.