The last two undefeated teams in the NFL are hitting the road in Week 6, which also features the final London game of the season.
The Baltimore Ravens and Tennessee Titans are duking it out on the other side of the pond over breakfast before the San Francisco 49ers head to Cleveland to take on the Browns.
The Philadelphia Eagles make the short hop north to face the New York Jets on a week where the Green Bay Packers and Pittsburgh Steelers are the only teams on a bye week.
Kansas City Chiefs
Tottenham Hotspur Stadium
TIAA Bank Field
Hard Rock Stadium
New Orleans Saints
San Francisco 49ers
Cleveland Browns Stadium
Las Vegas Raiders
New England Patriots
Tampa Bay Buccaneers
Raymond James Stadium
Los Angeles Rams
New York Jets
New York Giants
Los Angeles Chargers
|What||Baltimore Ravens @ Tennessee Titans|
|Where||Tottenham Hotspur Stadium, London, England|
|When||9.30am ET, Sunday, October 15th|
|How to watch||NFL Network|
|Odds||Ravens -4, Titans +160|
Baltimore and Tennessee will touch down in London still reeling from divisional losses with the Ravens having conspired to blow a 10-3 fourth quarter lead in a 17-10 defeat to Pittsburgh.
That loss leaves them in a tie for first with the Steelers in the AFC North and the last time they visited London, they were thrashed 44-14 by the Jacksonville Jaguars.
Another AFC South side stands in Baltimore’s way on Sunday morning in the Titans, who fell to 2-3 after a 23-16 loss to the Indianapolis Colts.
Tennessee are flying out on Thursday for their second-ever game in the UK after losing to the LA Chargers in 2018, while the Ravens landed on Monday to get acclimatised.
|What||Indianapolis Colts @ Jacksonville Jaguars|
|Where||TIAA Bank Stadium, Jacksonville, Florida|
|When||1pm ET, Sunday, October 15th|
|How to watch||CBS|
|Odds||Colts +170, Jaguars -4|
The Colts’ win over the Titans in Week 5 saw them improve to 3-2 and left them just behind this Sunday’s opponents Jacksonville, who sit at 3-2 but have the head-to-head tiebreaker.
That win was big for Indy but it came at a cost with exciting rookie quarterback Anthony Richardson suffering a sprained shoulder that will keep him out of action for several weeks.
Gardner Minshew stepped in to lead the Colts to victory against the Titans and will start in Jacksonville, the place where he made a name for himself in the NFL during a two-year stay.
The Jags now have Trevor Lawrence at quarterback and he recently outperformed Buffalo’s Josh Allen to complete a highly successful two-game stay in London for the Florida franchise as they beat both the Bills and Atlanta Falcons.
|What||San Francisco 49ers @ Cleveland Browns|
|Where||Cleveland Browns Stadium, Cleveland, Ohio|
|When||1pm ET, Sunday, October 15th|
|How to watch||Fox|
|Odds||49ers -5.5, Browns +185|
Deshaun Watson missed Cleveland’s final game before the bye week with a shoulder injury and there are fears he could be absent once more when the indomitable 49ers come to town.
Watson pulled out of the Week 4 28-3 defeat to the Baltimore Ravens after the pre-game warm-up and is still to return to practice with Browns head coach Kevin Stefanski guarded on his status when asked on Monday.
It could mean another start for rookie Dorian Thompson-Robinson, who had a debut to forget against Baltimore and could now face arguably the best defense in the NFL in San Francisco.
A Cleveland defense that’s held two of its first four opponents to three points might have something to say about that, but the 49ers look mightly impressive right now, demolishing the Dallas Cowboys in Week 5.
|What||New England Patriots @ Las Vegas Raiders|
|Where||Allegiant Stadium, Las Vegas, Nevada|
|When||4.05pm ET, Sunday, October 15th|
|How to watch||CBS|
|Odds||Patriots +135, Raiders -3|
Two of the men responsible for New England’s glorious run of success in the early 2000s will be standing on opposite sides of the field on Sunday when Bill Belichick’s Patriots travel to Las Vegas to take on the Josh McDaniels-coached Raiders.
Having celebrated six Super Bowl wins together when McDaniels worked under Belichick in Foxborough, life hasn’t gone to plan for either man since they parted ways with both sporting losing records this year.
The Pats are 1-4 after heavy losses to the Dallas Cowboys and New Orleans Saints, while the Raiders are 2-3 after an ugly win over the Green Bay Packers.
Both coaches are under mounting pressure and desperately need a win with Belichick having gone 0-2 against McDaniels in the past.
Las Vegas beat New England last season in a wild ending in which wide receiver Jakobi Meyers, now on the Raiders, threw an intercepted lateral on the final play of the game which Chandler Jones took back for a touchdown.
|What||Dallas Cowboys @ Los Angeles Chargers|
|Where||SoFi Stadium, Inglewood, California|
|When||8.15pm, Monday, October 16th|
|How to watch||ESPN|
|Odds||Cowboys -2, Chargers +110|
Week 6 wraps up with a high-profile Monday Night Football encounter between the Dallas Cowboys and Los Angeles Chargers.
Dallas is licking its wounds after being dismantled in San Francisco in a game where quarterback Dak Prescott threw three interceptions and the previously solid defense was run all over.
They now get the Chargers, fresh from a bye week and riding a two-game winning streak after nail-biting victories over the Raiders and Vikings.
While LA’s defence has held back the Bolts in the early stages, the offence under former Dallas offensive coordinator Kellen Moore has performed above expectations.
Moore was unceremoniously booted by the ‘Boys in the summer and will no doubt be relishing a crack at his old team.
Odds displayed within this article were correct at the time of writing and are subject to change.