The last two undefeated teams in the NFL are hitting the road in Week 6, which also features the final London game of the season.

The Baltimore Ravens and Tennessee Titans are duking it out on the other side of the pond over breakfast before the San Francisco 49ers head to Cleveland to take on the Browns. 

The Philadelphia Eagles make the short hop north to face the New York Jets on a week where the Green Bay Packers and Pittsburgh Steelers are the only teams on a bye week.

Week 6 Schedule, TV, Odds

Home	Away	Location	Time (ET)	TV	Money Line
Kansas City Chiefs	Denver Broncos	Arrowhead Stadium	8:15pm	Amazon Prime	Broncos +450 Chiefs -600
Tennessee Titans	Baltimore Ravens	Tottenham Hotspur Stadium	9: 30am	NFLN	Ravens -180 Titans +160
Atlanta Falcons	Washington Commanders	Mercedes-Benz Stadium	1pm	CBS	Commanders +120 Falcons -140
Cincinnati Bengals	Seattle Seahawks	Paycor Stadium	1pm	CBS	Seahawks +125 Bengals -145
Jacksonville Jaguars	Indianapolis Colts	TIAA Bank Field	1pm	CBS	Colts +170 Jaguars -200
Miami Dolphins	Carolina Panthers	Hard Rock Stadium	1pm	CBS	Panthers +600 Dolphins -900
Chicago Bears	Minnesota Vikings	Soldier Field	1pm	Fox	Vikings -145 Bears +125
Houston Texans	New Orleans Saints	NRG Stadium	1pm	Fox	Saints -125 Texans +105
Cleveland Browns	San Francisco 49ers	Cleveland Browns Stadium	1pm	Fox	49ers -225 Browns +185
Las Vegas Raiders	New England Patriots	Allegiant Stadium	4.05pm	CBS	Patriots +135 Raiders -155
Tampa Bay Buccaneers	Detroit Lions	Raymond James Stadium	4.25pm	Fox	Lions -170 Buccaneers +150
Los Angeles Rams	Arizona Cardinals	SoFi Stadium	4.25pm	Fox	Cardinals +230 Rams -280
New York Jets	Philadelphia Eagles	MetLife Stadium	4.25pm	Fox	Eagles -280 Jets +230
Buffalo Bills	New York Giants	Highmark Stadium	8.20pm	NBC, Peacock	Giants +600 Bills -900
Los Angeles Chargers	Dallas Cowboys	SoFi Stadium	8.15pm	ESPN, ABC	Cowboys -130 Chargers +110

Change of scene may aid Ravens and Titans

What	Baltimore Ravens @ Tennessee Titans
Where	Tottenham Hotspur Stadium, London, England
When	9.30am ET, Sunday, October 15th
How to watch	NFL Network
Odds	Ravens -4, Titans +160

Baltimore and Tennessee will touch down in London still reeling from divisional losses with the Ravens having conspired to blow a 10-3 fourth quarter lead in a 17-10 defeat to Pittsburgh. 

That loss leaves them in a tie for first with the Steelers in the AFC North and the last time they visited London, they were thrashed 44-14 by the Jacksonville Jaguars. 

Another AFC South side stands in Baltimore’s way on Sunday morning in the Titans, who fell to 2-3 after a 23-16 loss to the Indianapolis Colts. 

Tennessee are flying out on Thursday for their second-ever game in the UK after losing to the LA Chargers in 2018, while the Ravens landed on Monday to get acclimatised. 

Minshew mania returns to Jacksonville

What	Indianapolis Colts @ Jacksonville Jaguars
Where	TIAA Bank Stadium, Jacksonville, Florida
When	1pm ET, Sunday, October 15th
How to watch	CBS
Odds	Colts +170, Jaguars -4

The Colts’ win over the Titans in Week 5 saw them improve to 3-2 and left them just behind this Sunday’s opponents Jacksonville, who sit at 3-2 but have the head-to-head tiebreaker. 

That win was big for Indy but it came at a cost with exciting rookie quarterback Anthony Richardson suffering a sprained shoulder that will keep him out of action for several weeks.

Gardner Minshew stepped in to lead the Colts to victory against the Titans and will start in Jacksonville, the place where he made a name for himself in the NFL during a two-year stay.

The Jags now have Trevor Lawrence at quarterback and he recently outperformed Buffalo’s Josh Allen to complete a highly successful two-game stay in London for the Florida franchise as they beat both the Bills and Atlanta Falcons.

Watson worries for Browns ahead of Niners date

What	San Francisco 49ers @ Cleveland Browns
Where	Cleveland Browns Stadium, Cleveland, Ohio
When	1pm ET, Sunday, October 15th
How to watch	Fox
Odds	49ers -5.5, Browns +185

Deshaun Watson missed Cleveland’s final game before the bye week with a shoulder injury and there are fears he could be absent once more when the indomitable 49ers come to town. 

Watson pulled out of the Week 4 28-3 defeat to the Baltimore Ravens after the pre-game warm-up and is still to return to practice with Browns head coach Kevin Stefanski guarded on his status when asked on Monday.

It could mean another start for rookie Dorian Thompson-Robinson, who had a debut to forget against Baltimore and could now face arguably the best defense in the NFL in San Francisco. 

A Cleveland defense that’s held two of its first four opponents to three points might have something to say about that, but the 49ers look mightly impressive right now, demolishing the Dallas Cowboys in Week 5.

McDaniels comes up against old master

What	New England Patriots @ Las Vegas Raiders
Where	Allegiant Stadium, Las Vegas, Nevada
When	4.05pm ET, Sunday, October 15th
How to watch	CBS
Odds	Patriots +135, Raiders -3

Two of the men responsible for New England’s glorious run of success in the early 2000s will be standing on opposite sides of the field on Sunday when Bill Belichick’s Patriots travel to Las Vegas to take on the Josh McDaniels-coached Raiders.

Having celebrated six Super Bowl wins together when McDaniels worked under Belichick in Foxborough, life hasn’t gone to plan for either man since they parted ways with both sporting losing records this year. 

The Pats are 1-4 after heavy losses to the Dallas Cowboys and New Orleans Saints, while the Raiders are 2-3 after an ugly win over the Green Bay Packers. 

Both coaches are under mounting pressure and desperately need a win with Belichick having gone 0-2 against McDaniels in the past. 

Las Vegas beat New England last season in a wild ending in which wide receiver Jakobi Meyers, now on the Raiders, threw an intercepted lateral on the final play of the game which Chandler Jones took back for a touchdown.

Chargers in need of Moore

What	Dallas Cowboys @ Los Angeles Chargers
Where	SoFi Stadium, Inglewood, California
When	8.15pm, Monday, October 16th
How to watch	ESPN
Odds	Cowboys -2, Chargers +110

Week 6 wraps up with a high-profile Monday Night Football encounter between the Dallas Cowboys and Los Angeles Chargers. 

Dallas is licking its wounds after being dismantled in San Francisco in a game where quarterback Dak Prescott threw three interceptions and the previously solid defense was run all over.

They now get the Chargers, fresh from a bye week and riding a two-game winning streak after nail-biting victories over the Raiders and Vikings.

While LA’s defence has held back the Bolts in the early stages, the offence under former Dallas offensive coordinator Kellen Moore has performed above expectations. 

Moore was unceremoniously booted by the ‘Boys in the summer and will no doubt be relishing a crack at his old team. 

Odds displayed within this article were correct at the time of writing and are subject to change.