There are no unbeaten teams left in the NFL after both the San Francisco 49ers and Philadelphia Eagles lost on a Sunday of shocks.

Both teams had set the standard in the NFC, but they have now been brought back down to earth.

The 49ers looked to be cruising against the Cleveland Browns, only to lose 19-17 on the road, while the New York Jets came from behind to beat the Eagles 20-14.

We take a look at the biggest talking points from the sixth week of NFL contests.

NFC teams on notice after surprise defeats

There are now five teams with 5-1 records in the NFL after Sunday's shock results.

The Eagles and 49ers had looked a class apart, but the NFL once again delivered for the neutrals.

After five weeks of joy, things unravelled for the 49ers in Cleveland, as they lost both Christian McCaffrey and Deebo Samuel to injury.

A pre-game scuffle broke out before kickoff, and it certainly fired up the Browns as they handed 49ers quarterback Brock Purdy his first regular-season defeat.

The 49ers had the chance to win it at the death, only for rookie kicker Jake Moody to miss his 41-yard field goal.

Sunday's win for the Browns was even more impressive as they had PJ Walker at quarterback, with Deshaun Watson nursing a shoulder injury.

The 49ers remain the +425 favorites to win the NFL Championship, closely followed by the Kansas City Chiefs, who are +500 to succeed for the second year in a row.

Eagles' wings clipped by soaring Jets

The NFL does storylines better than everyone else. The first chapter of the 2023 New York Jets was ruined after the first sentence when quarterback Aaron Rodgers went down injured with a torn Achilles.

After beating the Buffalo Bills, the Jets lost to the Dallas Cowboys, New England Patriots and Chiefs. But back-to-back wins have breathed new life into Robert Saleh's team ahead of their bye week.

Zach Wilson avoided any errors against the Eagles, but it was the Jets' defense that won them the game. They picked off Eagles QB Jalen Hurts on three occasions and showed they mean business this season.

Odds of +700 for the Eagles to win the NFL Championship suggest Sunday's result is merely a blip, but it has boosted the Jets' playoff chances, and they are +390 to reach the postseason.

Dolphins and Lions continue their march

The Eagles will be desperate to return to winning ways as soon as possible, but they face the Miami Dolphins in week 7. Miami beat the Carolina Panthers 42-21 to improve their record to 5-1, and they once again look so dangerous on offense.

The NFL's top receiver, Tyreek Hill, caught another touchdown, while Raheem Mostert ran the Panthers' defense into submission. QB Tua Tagovaiola threw another three touchdown passes, and things are looking good for the Dolphins.

They are -150 to win the AFC East, while the Detroit Lions also moved to 5-1 after their 20-6 win over the Tampa Bay Buccaneers.

Dan Campbell's team have won 13 of their previous 16 games, which is their best run since the 1960s.

New England's pain continues

The New England Patriots were the dominant force in the NFL just a few years ago, but the walls are crumbling around coach Bill Belichick.

While they were competitive in their 21-17 defeat to the Las Vegas Raiders, they have now lost three matches in a row.

Belichick may need to completely rip up the Patriots roster if he is to succeed in the next few years, but he may not get the time to do that.

Elsewhere in the AFC, the Cincinnati Bengals improved their record to 3-3 as they try to keep pace with their rivals in the AFC North.

Joe Burrow and co had to hang on against the Seattle Seahawks, but they ran out 17-13 winners to keep their season alive. Sadly for them, AFC North rivals Baltimore Ravens won 24-16 in the last London game of 2023.

Both the Houston Texans and Jacksonville Jaguars were victorious in their games against the Indianapolis Colts and New Orleans Saints. The Jaguars won 37-20, while the Texans squeezed past the Saints 20-13.

Kirk Cousins and the Minnesota Vikings beat the Chicago Bears 19-13 without Justin Jefferson, while the Washington Commanders battled past the Atlanta Falcons to win 24-16.

The Arizona Cardinals continue to struggle as they lost 26-9 to the Los Angeles Rams, while the Buffalo Bills scraped past the New York Giants, winning 14-9.