The opening weekend of the new NFL season delivered with exciting games, shock results, and plenty of storylines to keep an eye on as we look ahead to Week 2.

Here's all you need to know about the Week 2 matchups and our top five games to watch.

NFL Week 2 Schedule, How to Watch, Odds

Home	Away	Location	Time (ET)	TV	Spread
Philadelphia Eagles	Minnesota Vikings	Lincoln Financial Field	8:15 PM (Thursday)	Amazon Prime	Eagles -6
Atlanta Falcons	Green Bay Packers	Mercedes-Benz Stadium	1 PM	Fox	Packers -1
Detroit Lions	Seattle Seahawks	Ford Field	1 PM	Fox	Lions -4.5
Tampa Bay Buccaneers	Chicago Bears	Raymond James Stadium	1 PM	Fox	Buccaneers -2.5
Houston Texans	Indianapolis Colts	NRG Stadium	1 PM	Fox	Colts -1
Buffalo Bills	Las Vegas Raiders	Highmark Stadium	1 PM	CBS, Paramount +	Bills -9.5
Cincinnati Bengals	Baltimore Ravens	Paycor Stadium	1 PM	CBS, Paramount +	Bengals -3.5
Tennessee Titans	Los Angeles Chargers	Nissan Stadium	1 PM	CBS, Paramount +	Chargers -3
Jacksonville Jaguars	Kansas City Chiefs	TIAA Bank Field	1 PM	CBS, Paramount +	Chiefs -3.5
Los Angeles Rams	San Francisco 49ers	SoFi Stadium	4:05 PM	Fox	49ers -8
Arizona Cardinals	New York Giants	State Farm Stadium	4:05 PM	Fox	Giants -5.5
Dallas Cowboys	New York Jets	AT&T Stadium	4:25 PM	CBS, Paramount +	Cowboys -9
Denver Broncos	Washington Commanders	Empower Field at Mile High	4:25 PM	CBS, Paramount +	Broncos -3.5
New England Patriots	Miami Dolphins	Gillette Stadium	8:20 PM	NBC	Dolphins -3
Carolina Panthers	New Orleans Saints	Bank of America Stadium	7:15 PM (Monday)	ESPN	Saints -3
Pittsburgh Steelers	Cleveland Browns	Acrisure Stadium	8:15 PM (Monday)	ABC	Browns -2.5

NFL Week 2 Games to Watch 

Eagles looking to clean up

What	Minnesota Vikings @ Philadelphia Eagles
Where	Lincoln Financial Field, Philadelphia, Pennsylvania
When	8:15 PM ET, Thursday, September 14th
How to watch	Amazon Prime
Odds	Eagles -6, Vikings +215 ML

The defending NFC champions got off to an inauspicious but winning start last week when they held off the New England Patriots at Gillette Stadium. 

It was not pretty as miscues on both sides of the ball almost cost them the W with head coach Nick Sirianni admitting the Eagles had "a lot of things to clean up."

Philadelphia's defense is much changed from the dominant unit of last season with five new starters and three new coaches, including DC Sean Desai. 

So it will be compelling to see how they handle reigning Offensive Player of the Year Justin Jefferson streaking through their secondary. 

Vikings QB Kirk Cousins, who has a 12-20 prime-time record as a starter, has more to prove after being responsible for three turnovers in Minnesota's Week 1 loss to Tampa Bay. 

Seahawks in for a Week 2 challenge

What	Seattle Seahawks @ Detroit Lions
Where	Ford Field, Detroit, Michigan
When	1:00 PM ET, Sunday, September 17th
How to watch	Fox
Odds	Lions -4.5, Seahawks +185 ML

Detroit will look to back up the performance they produced to beat the Kansas City Chiefs in last Thursday's Kickoff Game when they face the team that edged them out of the playoffs last January. 

The Seahawks lost their opener in humiliating fashion after taking a 13-7 halftime lead over the Los Angeles Rams. 

Seattle's offense ground to a halt after the break, totaling just 12 yards — their lowest output in any half since at least 1991 — in an eventual 27-13 home loss. 

The Lions' defense shut down the reigning Super Bowl champions by pressuring Patrick Mahomes into 18 incompletions and will aim to make things equally uncomfortable for Seahawks QB Geno Smith. 

Mahomes looks for rebound win

What	Kansas City Chiefs @ Jacksonville Jaguars
Where	TIAA Bank Field, Jacksonville, Florida
When	1:00 PM ET, Sunday, September 17th
How to watch	CBS, Paramount +
Odds	Chiefs -3.5, Jaguars +155 ML

Mahomes is 13-3 in the weeks following a loss, so many will be tuning into this one expecting to see the quarterback lead Kansas City to their first win of the season. 

But the status of tight end Travis Kelce probably has more relevance to the outcome of the game as Mahomes' comfort blanket was badly missed in last week's loss to the Lions. 

The extra days off give his the knee injury time to heal. 

And that could spell trouble for the Jags, who surrendered 1,066 yards to tight ends last year — the fourth most in the NFL — and were burned by Kelce for two touchdowns in the playoffs. 

Jets must go without Rodgers  

What	New York Jets @ Dallas Cowboys
Where	AT&T Stadium, Arlington, Texas
When	4:25 PM ET, Sunday, September 17th
How to watch	CBS, Paramount +
Odds	Cowboys -9, Jets +350 ML

The line for this one shifted greatly with the news of Aaron Rodgers' season-ending injury as the former Green Bay Packers star had been known as a Dallas killer in the past.

The Cowboys will not fear Jets starter Zach Wilson, who got more than just a bit of help from Josh Allen's poor play in guiding New York to victory over the Buffalo Bills on Monday Night Football.

Dallas produced the most dominant win of Week 1, crushing their NFC East rivals the New York Giants 40-0. 

They were particularly impressive on defense with Micah Parsons, Stephon Gilmore, DeMarcus Lawrence and Trevon Diggs leading a fearsome unit. 

The Jets' defense recorded five sacks and forced four turnovers against the Bills, so they will likely present a bigger challenge than their New York counterparts in Week 1.

Steelers set for fiery showdown 

What	Cleveland Browns @ Pittsburgh Steelers
Where	Acrisure Stadium, Pittsburgh, Pennsylvania
When	8:15 PM ET, Monday, September 18th
How to watch	ABC
Odds	Browns -2.5, Steelers +115 ML

AFC North clashes rarely disappoint and there should be plenty of big hits when the Browns attempt to move to 2-0 against a Steelers team desperate to bounce back from their Week 1 mauling by the San Francisco 49ers. 

Another win for Cleveland would put them in a very strong position in the division after their upset of the Cincinnati Bengals last week. 

But the Steelers have won an NFL-record 20 straight Monday night games at home and have beaten the Browns 19 straight times at home in the regular season, so history suggests Pittsburgh will pull out a victory.  

Odds displayed within this article were correct at the time of writing and are subject to change.