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NFL Week 2: Schedule, Odds, Games to watch

The opening weekend of the new NFL season delivered with exciting games, shock results, and plenty of storylines to keep an eye on as we look ahead to Week 2.

Here's all you need to know about the Week 2 matchups and our top five games to watch.

NFL Week 2 Schedule, How to Watch, Odds

Home 

Away 

Location 

Time (ET) 

TV 

Spread 

Philadelphia Eagles 

Minnesota Vikings 

Lincoln Financial Field 

8:15 PM (Thursday) 

Amazon Prime 

Eagles -6 

Atlanta Falcons 

Green Bay Packers 

Mercedes-Benz Stadium 

1 PM 

Fox 

Packers -1

Detroit Lions 

Seattle Seahawks 

Ford Field 

1 PM 

Fox 

Lions -4.5

Tampa Bay Buccaneers 

Chicago Bears 

Raymond James Stadium 

1 PM 

Fox 

Buccaneers -2.5

Houston Texans 

Indianapolis Colts 

NRG Stadium 

1 PM 

Fox 

Colts -1

Buffalo Bills 

Las Vegas Raiders 

Highmark Stadium 

1 PM 

CBS, Paramount + 

Bills -9.5 

Cincinnati Bengals 

Baltimore Ravens 

Paycor Stadium 

1 PM 

CBS, Paramount + 

Bengals -3.5 

Tennessee Titans 

Los Angeles Chargers 

Nissan Stadium 

1 PM 

CBS, Paramount + 

Chargers -3

Jacksonville Jaguars 

Kansas City Chiefs 

TIAA Bank Field 

1 PM 

CBS, Paramount + 

Chiefs -3.5

Los Angeles Rams 

San Francisco 49ers 

SoFi Stadium 

4:05 PM 

Fox 

49ers -8

Arizona Cardinals 

New York Giants 

State Farm Stadium 

4:05 PM 

Fox 

Giants -5.5

Dallas Cowboys 

New York Jets 

AT&T Stadium 

4:25 PM 

CBS, Paramount + 

Cowboys -9

Denver Broncos 

Washington Commanders 

Empower Field at Mile High 

4:25 PM 

CBS, Paramount + 

Broncos -3.5 

New England Patriots 

Miami Dolphins 

Gillette Stadium 

8:20 PM 

NBC 

Dolphins -3

Carolina Panthers 

New Orleans Saints 

Bank of America Stadium 

7:15 PM (Monday) 

ESPN 

Saints -3

Pittsburgh Steelers 

Cleveland Browns 

Acrisure Stadium 

8:15 PM (Monday) 

ABC 

Browns -2.5

NFL Week 2 Games to Watch 

Eagles looking to clean up

What  Minnesota Vikings @ Philadelphia Eagles 
Where  Lincoln Financial Field, Philadelphia, Pennsylvania
When  8:15 PM ET, Thursday, September 14th 
How to watch  Amazon Prime 
Odds  Eagles -6, Vikings +215 ML

The defending NFC champions got off to an inauspicious but winning start last week when they held off the New England Patriots at Gillette Stadium. 

It was not pretty as miscues on both sides of the ball almost cost them the W with head coach Nick Sirianni admitting the Eagles had "a lot of things to clean up."

Philadelphia's defense is much changed from the dominant unit of last season with five new starters and three new coaches, including DC Sean Desai. 

So it will be compelling to see how they handle reigning Offensive Player of the Year Justin Jefferson streaking through their secondary. 

Vikings QB Kirk Cousins, who has a 12-20 prime-time record as a starter, has more to prove after being responsible for three turnovers in Minnesota's Week 1 loss to Tampa Bay. 

Seahawks in for a Week 2 challenge

What  Seattle Seahawks @ Detroit Lions 
Where  Ford Field, Detroit, Michigan
When  1:00 PM ET, Sunday, September 17th 
How to watch  Fox 
Odds  Lions -4.5, Seahawks +185 ML

Detroit will look to back up the performance they produced to beat the Kansas City Chiefs in last Thursday's Kickoff Game when they face the team that edged them out of the playoffs last January. 

The Seahawks lost their opener in humiliating fashion after taking a 13-7 halftime lead over the Los Angeles Rams. 

Seattle's offense ground to a halt after the break, totaling just 12 yards — their lowest output in any half since at least 1991 — in an eventual 27-13 home loss. 

The Lions' defense shut down the reigning Super Bowl champions by pressuring Patrick Mahomes into 18 incompletions and will aim to make things equally uncomfortable for Seahawks QB Geno Smith. 

Mahomes looks for rebound win

What  Kansas City Chiefs @ Jacksonville Jaguars 
Where  TIAA Bank Field, Jacksonville, Florida 
When  1:00 PM ET, Sunday, September 17th 
How to watch  CBS, Paramount + 
Odds  Chiefs -3.5, Jaguars +155 ML

Mahomes is 13-3 in the weeks following a loss, so many will be tuning into this one expecting to see the quarterback lead Kansas City to their first win of the season. 

But the status of tight end Travis Kelce probably has more relevance to the outcome of the game as Mahomes' comfort blanket was badly missed in last week's loss to the Lions. 

The extra days off give his the knee injury time to heal. 

And that could spell trouble for the Jags, who surrendered 1,066 yards to tight ends last year — the fourth most in the NFL — and were burned by Kelce for two touchdowns in the playoffs. 

Jets must go without Rodgers  

What  New York Jets @ Dallas Cowboys 
Where  AT&T Stadium, Arlington, Texas
When  4:25 PM ET, Sunday, September 17th 
How to watch  CBS, Paramount + 
Odds  Cowboys -9, Jets +350 ML

The line for this one shifted greatly with the news of Aaron Rodgers' season-ending injury as the former Green Bay Packers star had been known as a Dallas killer in the past.

The Cowboys will not fear Jets starter Zach Wilson, who got more than just a bit of help from Josh Allen's poor play in guiding New York to victory over the Buffalo Bills on Monday Night Football.

Dallas produced the most dominant win of Week 1, crushing their NFC East rivals the New York Giants 40-0. 

They were particularly impressive on defense with Micah Parsons, Stephon Gilmore, DeMarcus Lawrence and Trevon Diggs leading a fearsome unit. 

The Jets' defense recorded five sacks and forced four turnovers against the Bills, so they will likely present a bigger challenge than their New York counterparts in Week 1.

Steelers set for fiery showdown 

What  Cleveland Browns @ Pittsburgh Steelers 
Where  Acrisure Stadium, Pittsburgh, Pennsylvania
When  8:15 PM ET, Monday, September 18th 
How to watch  ABC 
Odds  Browns -2.5, Steelers +115 ML

AFC North clashes rarely disappoint and there should be plenty of big hits when the Browns attempt to move to 2-0 against a Steelers team desperate to bounce back from their Week 1 mauling by the San Francisco 49ers. 

Another win for Cleveland would put them in a very strong position in the division after their upset of the Cincinnati Bengals last week. 

But the Steelers have won an NFL-record 20 straight Monday night games at home and have beaten the Browns 19 straight times at home in the regular season, so history suggests Pittsburgh will pull out a victory.  

Odds displayed within this article were correct at the time of writing and are subject to change.

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