Kansas City Chiefs vs. San Francisco 49ers: Picks, Predictions, Odds and Player Props

Sitting at 5-0 ahead of their trip to Santa Clara on Sunday, it's been a perfect start to the season for the Kansas City Chiefs as they prepare to face the San Francisco 49ers.

Levi’s Stadium will provide the stage for a rematch of last season’s NFL Championship game in which the Chiefs earned a 25-22 OT win against the 49ers at Allegiant Stadium in Paradise, Nevada.

The Chiefs have enjoyed a perfect start to their title defense, beating the Baltimore Ravens, Cincinnati Bengals, Atlanta Falcons, Los Angeles Chargers and New Orleans Saints this season.

As for the 49ers, overcoming the hangover of a NFL Championship defeat is never easy and San Fran has had a mixed bag of results en route to their 3-3 record. They beat the New York Jets in Week 1, lost to the Minnesota Vikings and Los Angeles Rams, beat the New England Patriots, and then lost to the Arizona Cardinals.

A 36-24 win on the road at the Seattle Seahawks will have boosted morale in the 49ers camp, but arguably their toughest game of the season awaits against the reigning champs on Sunday.

Kansas City Chiefs vs. San Francisco 49ers betting picks and predictions

Kansas City Chiefs to win (+100)

The Chiefs have enjoyed this matchup over the years, with Kansas City winning six of their last seven meetings with San Francisco.

KC has also won all of their last four encounters with the 49ers, indicating that the Chiefs have San Francisco’s number. And, there have been signs that the winning streak for Kansas City can continue this weekend.

A home defeat to the Cardinals caught many by surprise, but Arizona showed in that game at Levi’s Stadium how to get at this 49ers team.

The Chiefs will look to follow the Cardinals’ lead and make a strong start to the game, as Arizona quarterback Kyler Murray did with a 50-yard rushing touchdown.

Patrick Mahomes is unlikely to go from that sort of range, but he is a playmaker who can get the Chiefs on the front foot early.

The Chiefs did just that in their last game against the Saints, scoring the first touchdown of the game to take a 7-0 lead into the second quarter at Arrowhead Stadium.

Kansas City have a good blend on offense with aerial threats and the trio of Kareem Hunt, Isaiah Pacheco and Carson Steele who shared the load in the running game.

The 49ers defense has been solid for much of the season, but Mahomes and the Chiefs have the weapons on offense to get the job done in Santa Clara and make it five straight wins against the 49ers.

Over 46.5 total points (-110)

Looking back at the Chiefs’ most recent visit to Levi’s Stadium in October 2022, Kansas City ran amok that day, winning 44-23 in California.

This game has tended to have plenty of points in recent years and going with Over this game's 46.5 total points would have landed in all of the last four meetings between these teams.

With the attacking talent on show and with Mahomes and Brock Purdy getting set to face off in the battle of the QBs, another high-scoring shootout can be expected at Levi’s Stadium this weekend.

Read more betting picks and predictions for the NFL on site.

Kansas City Chiefs vs. San Francisco 49ers odds

Kansas City Chiefs	+100 ML
San Francisco 49ers	-120 ML
Spread	SF 49ers -1.0
Total Points	O/U 46.5

Kansas City Chiefs vs. San Francisco 49ers player props

Anytime Touchdown

Jordan Mason (SF 49ers)	-105
Kareem Hunt (KC Chiefs)	+105
Isaac Guerendo (SF 49ers)	+105
Travis Kelce (KC Chiefs)	+130
Deebo Samuel (SF 49ers)	+125
Xavier Worthy (KC Chiefs)	+175

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This article was written by a partner sports writer via Spotlight Sports Group. All odds displayed on this page were correct at the time of writing and are subject to withdrawal or change at any time.