Jacksonville Jaguars vs. Buffalo Bills: Picks, Predictions, Odds and Player Props

As part of a Monday Night Football double-header in Week 3 of the NFL season, the Buffalo Bills host the Jacksonville Jaguars.

The all-AFC showdown is between a winless Jacksonville team and an undefeated Buffalo squad and needless to say, the Jags (0-2) are in desperate need of a victory.

For the Bills (2-0), they are trying to maintain their solo lead at the top the AFC East – the New York Jets already won on Thursday Night Football this week, improving to 2-1.

Jacksonville Jaguars vs. Buffalo Bills betting picks and predictions 

Jacksonville Jaguars +5 (-105)

There were some questions about Buffalo’s offense heading into this season given the departure of wide receiver Stefon Diggs to the Houston Texans, but it’s safe to say now that not much has changed with Josh Allen still under center.

The Bills exceeded the 30-point mark in each of their first two contests, scraping past the Arizona Cardinals 34-28 before hammering the Miami Dolphins 31-10.

However, the result against Miami probably wasn’t as impressive as the score suggests. Two terrible turnovers by Tua Tagovailoa, before he unfortunately suffered another concussion, were significant contributions to Buffalo’s cause.

Allen and company also got away with a dreadful start against Arizona, as they trailed 17-3 late in the second half.

Despite hosting a winless opponent, this is no easy spot for the Bills. The Jaguars are certainly better than their 0-2 indicates. They lost the Miami and the Cleveland Browns by a combined eight points to begin their 2024 campaign and have suffered some bad luck in each of those two setbacks.

Jacksonville’s defense has been stellar, while Trevor Lawrence and the offense should be able to improve at the expense of a Buffalo defense that is already dealing with injuries at the linebacker and defensive back spots.

In what could be a competitive and relatively low-scoring affair, five points should be enough for the visitors to cover.

Under 45.5 (-110)

Jacksonville held a potent Dolphins offense, with Tagovailoa healthy at the time, to just 20 points and limited the Browns to 18.

The Jaguars are 10th league-wide in EPA per rush and 10th in opponent rushing success rate, which bodes well for their chances of containing Buffalo’s running game.

Even if the Bills sustain some decent drives, they will likely be slow and methodical. As for the Bills’ defense, it is currently a top-10 unit in EPA per play, EPA per pass and EPA per rush, even though it has been without three of its best players.

Von Miller, Daquon Jones, Greg Rousseau and Ed Oliver have all impressed up front through two weeks. Buffalo may not completely shut down Lawrence and the Jags, but they should at least keep them somewhat in check.

It is worth noting that Jacksonville has not yet exceeded the 17-point mark this season and its franchise QB has thrown just a single touchdown pass.

So, all things considered, the under looks like a strong play.

Read more betting picks and predictions for the NFL on site.

Jacksonville Jaguars vs. Buffalo Bills odds

Jacksonville Jaguars	-200 ML
Buffalo Bills	+245 ML
Spread	BUF -5
Total Points	O/U 45.5

Jacksonville Jaguars vs. Buffalo Bills player props

Anytime Touchdown

Travis Etienne (JAX)	+105
Christian Kirk (JAX)	+225
Brian Thomas Jr. (JAX)	+250
James Cook (BUF)	-110
Josh Allen (BUF)	-110
Dalton Kincaird (BUF)	+210

This article was written by a partner sports writer via Spotlight Sports Group. All odds displayed on this page were correct at the time of writing and are subject to withdrawal or change at any time.