Houston Texans vs. Kansas City Chiefs: Picks, Predictions, Odds and Player Props

The Kansas City Chiefs will look to win their 14th game of the season when they play host to the Houston Texans at GEHA Field at Arrowhead Stadium in Week 16 of the 2024 NFL season.

Andy Reid's team are the top dogs in the AFC with a 13-1 record, and the reigning champions are on track to defend their crown if they can maintain their recent standards.

Like Kansas City, the Texans have clinched their division and the AFC South champions have momentum behind them after winning two games in a row either side of their bye in Week 14.

Houston Texans vs. Kansas City Chiefs betting picks and predictions

Kansas City Chiefs -3.0 (-105)

When the spread was announced for Saturday's game, the Chiefs were underdogs for only the third time this season.

An injury to quarterback Patrick Mahomes during the 21-7 win over the Cleveland Browns last weekend caused everyone to panic, but the fan favorite is expected to play on Saturday.

Mahomes has not suffered a broken ankle or a severe high-ankle sprain as expected and he claims he will play as long as his team are not placed in a "bad position".

News of Mahomes' return to practice soon saw the Chiefs installed as favorites and they should be able to justify that.

While the Texans have won back-to-back games, they have lost three of their last six, losing to the New York Jets and Tennessee Titans.

DeMeco Ryans' team have not improved upon last season like they were expected to, while the Chiefs have continued to grind out results and get the job done.

Reid's team has won so many close games this season, and with home advantage, the Chiefs should rack up another victory by at least a field goal.

Under 41.5 total points (-110)

The Chiefs have been impressive defensively this season, conceding 18.5 points per game on average, which is the fifth-best in the NFL. Houston is not too far behind, allowing only 21.4 points per game in the 14 they have played.

Kansas City should trouble Houston quarterback C.J. Stroud who has regressed this season, but they may also struggle on offense themselves.

If Mahomes is not fully fit, KC may need to run the ball more and take the pressure off their quarterback, and this game could turn into a dogfight in the trenches.

Joe Mixon Under 60.5 rushing yards (-110)

While Mahomes has been and always will be key to the Chiefs' success, Reid's defense has played at a high level all season. Kansas City has held running backs to 3.9 yards per carry, which is the second-fewest in the NFL.

They have only allowed 91.9 yards per game on the ground, which means Houston running back Joe Mixon could be in for a rough afternoon.

Houston's run game has been inconsistent since Week 9, and Mixon has either finished with over 100 yards or gone under 50 since then.

He has recorded fewer than 25 yards in two of his last three outings, and against a resolute Chiefs defense, he should struggle.

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Houston Texans vs. Kansas City Chiefs odds

Houston Texans	+130 ML
Kansas City Chiefs	-155 ML
Spread	KC Chiefs -3.0
Total Points	O/U 41.5

Houston Texans vs. Kansas City Chiefs player props

Anytime Touchdown

Joe Mixon (HOU Texans)	-138
Isiah Pacheco (KC Chiefs)	+140
Nico Collins (HOU Texans)	+150
Travis Kelce (KC Chiefs)	+160
Kareem Hunt (KC Chiefs)	+187
DeAndre Hopkins (KC Chiefs)	+220
Tank Dell (HOU Texans)	+260

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This article was written by a partner sports writer via Spotlight Sports Group. All odds displayed on this page were correct at the time of writing and are subject to withdrawal or change at any time.