Two teams that have madecontrasting starts to the 2026 NFL season meet at Highmark Stadium on Sunday as Buffalo Bills host Los Angeles Chargers.
Buffalo sits at the top of the AFC East after winning both of their games, while the Chargers are at the bottom of the AFC West after successive defeats.
The two teams last met in December 2023, with Buffalo winning 24-22, but the Bills are expected to win comfortably this week as they play in their new stadium for just the second time.
Chargers vs. Bills betting tips and predictions
Buffalo Bills -7.5 (+100)
The Bills were considered one of the favorites to win the NFL championship in the summer and they have hit the ground running under new head coach Joe Brady.
They opened the season with a 36-31 win over Houston Texans before they secured a 41-31 victory over Detroit Lions.
Buffalo's charge has been led by their quarterback, Josh Allen, and he has been instrumental in their success.
Allen has thrown five touchdowns and run for four more in two games, and he should be able to help his team cover the spread.
The Chargers have only scored 14 points in each of their two games, and there should be little resistance from Jim Harbaugh's team.
Harbaugh has been unable to guide his team to a victory, with the Chargers losing 26-14 to Arizona Cardinals in Week 1, while they lost by the same scoreline to Las Vegas Raiders.
Neither the Cardinals nor the Raiders are expected to challenge for the playoffs this season, which suggests the Bills could run riot if they keep up their recent performances on offense.
Over 50.5 Points (-105)
The Chargers have struggled to click on offense, despite hiring Mike McDaniel as their offensive coordinator.
Chargers quarterback Justin Herbert has yet to find his groove, but the Buffalo secondary has struggled so far. They have been unable to limit opposing quarterbacks and have conceded 31 points in their opening two games.
The Bills should be able to push towards 50 points on their own, but if Herbert settles down, expect the Chargers to have the chance to score a touchdown or two.
Josh Allen over 250 passing yards (+115)
The Chargers have allowed Jacoby Brissett and Kirk Cousins to throw for over 250 yards already and that should give Allen plenty of confidence ahead of kickoff.
Allen has surpassed 240 yards in both outings, while he racked up 334 against the Texans in Week 1.
With Allen, a true dual-threat quarterback, the Chargers' defense will have to keep guessing what he is going to do, and he is more than happy to carry the team forward single-handedly.
Harbaugh's team have conceded 262.5 passing yards per game so far and on the road in Buffalo is one of the toughest assignments for any defense.
The home crowd will be fired up for this clash as the Bills look to move to 3-0 and Allen has the skills to carve them open.
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Chargers vs. Bills odds
Los Angeles Chargers | +275 |
Buffalo Bills | -350 |
Spread | BUF Bills -7.5 |
Total | O/U 50.5 |
Chargers vs. Bills player props
Anytime touchdown
James Cook (BUF Bills) | -230 |
Josh Allen (BUF Bills) | -175 |
Omarion Hampton (LA Chargers) | -130 |
DJ Moore (BUF Bills) | +140 |
Khalil Shakir (BUF Bills) | +165 |
Ladd McConkey (LA Chargers) | +195 |
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This article was written by a partner sports writer via Spotlight Sports Group. All odds displayed on this page were correct at the time of writing and are subject to withdrawal or change at any time.
