Buffalo Bills vs. Los Angeles Rams: Picks, Predictions, Odds and Player Props

The Buffalo Bills clash with the Los Angeles Rams at SoFi Stadium in LA this weekend, and it is one of the standout games in Week 14 of the 2024 NFL campaign.

It is an especially crucial contest for Los Angeles, which is 6-6 and in battles for both the NFC West crown and a Wild Card spot.

Buffalo (10-2) has already clinched the AFC East title, but it wants to continue its charge for the No. 1 seed in the AFC.

With the game kicking off at 4:25 PM ET on FOX, it’s time to break down the Bills vs. Rams matchup and discuss the best bets to make.

Buffalo Bills vs. Los Angeles Rams betting picks and predictions

Buffalo Bills -4.0 (-105)

Despite having already wrapped up a division title and at least one home game in the playoffs, the Bills won’t be taking their foot off the gas.

They are just one game behind the Kansas City Chiefs for the top spot in the conference and would emerge victorious in that effort in the event of a tie based on their head-to-head result in Week 11 (Buffalo prevailed 30-21 at home).

That is part of a seven-game winning streak for Buffalo, with five of those victories coming against potential playoff teams and five of them coming by at least nine points.

Sean McDermott’s squad most recently destroyed the San Francisco 49ers 35-10 this past Sunday night.

As for the Rams, SoFi Stadium has never been much of a home-court advantage. This season is no exception, as Los Angeles has lost three times inside its own venue – including twice in a row to the Miami Dolphins and Philadelphia Eagles, the latter via a 37-20 score in Week 12.

The Rams’ defense is not particularly adept against either the run or the pass, which is problematic when the Bills can beat you in so many different ways from an offensive standpoint. That's why we like Buffalo to cover in LA this week.

Over 49.5 Total Points (-110)

Even with what Saquon Barkley is doing in Philadelphia, Buffalo quarterback Josh Allen is currently a significant favorite to win NFL MVP.

He is the biggest reason why the Bills are No. 2 in the NFL in scoring offense at 29.6 points per game, trailing only the Detroit Lions.

Allen (26 total touchdowns, five interceptions) and company have put up at least 30 points in a whopping six consecutive contests.

The Rams’ defense is No. 28 in the league against the run and right in the middle against the pass, so it’s hard to see them doing much to contain the Bills.

On the more productive offensive side of the ball, LA QB Matthew Stafford has receivers Cooper Kupp and Puka Nacua back at his disposal.

Not counting an early ejection in Week 9, Nacua has 546 yards in just six games this season. Kupp has eclipsed the 100-yard mark in two of the last five outings and has scored three touchdowns in the last three.

All things considered, you should feel much more comfortable playing the Over with these two potent offenses. 

James Cook anytime touchdown scorer (-138)

You can never unequivocally say that someone is a lock to score a touchdown, but Bills RB Cook is close to earning such a distinction.

At very reasonable -138 odds, he certainly has great value on Sunday. Cook has scored at least one touchdown in six of the last seven contests and in eight of the last 10.

This season, he has as many multi-touchdown games as he has scoreless games (three). He is simply a TD-scoring machine in 2024.

The University of Georgia product has found the endzone 12 times overall this season (11 rushing, one receiving). He now faces a Los Angeles defense that has allowed 10 touchdowns on the ground and 4.6 yards per carry.

Read more betting picks and predictions for the NFL on site.

Buffalo Bills vs. Los Angeles Rams odds

Buffalo Bills	+200 ML
Los Angeles Rams	-165 ML
Spread	BUF Bills -4.0
Total Points	O/U 49.5

Buffalo Bills vs. Los Angeles Rams player props

Anytime Touchdown

James Cook (BUF)	+138
Josh Allen (BUF)	-110
Amari Cooper (BUF)	-160
Kyren Williams (LAR)	+175
Cooper Kupp (LAR)	-150
Puka Nacua (LAR)	-150

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This article was written by a partner sports writer via Spotlight Sports Group. All odds displayed on this page were correct at the time of writing and are subject to withdrawal or change at any time.