Buffalo Bills vs. Detroit Lions: Picks, Predictions, Odds and Player Props

The most eagerly awaited game of Week 15 is an afternoon showdown between the Buffalo Bills and the Detroit Lions at Ford Field.

It's a clash of two championship contenders and a potential preview of the title game itself as the 12-1 Lions host the 10-3 Bills.

Detroit is currently on an 11-game winning streak. The Bills were not far behind, having been on a seven-game winning run of their own before going down 44-42 to the Los Angeles Rams in a thriller last week.

The Bills are in a more comfortable position, having already clinched the AFC East with a month to spare, while the Lions can't afford to slip up as they have the 11-2 Minnesota Vikings breathing down their necks in the loaded NFC North.

Buffalo has won the teams' last four meetings, but their most recent encounter in 2022 was close and high-scoring as the AFC team won 28-25 in Michigan.

Buffalo Bills vs. Detroit Lions betting picks and predictions

Over 54.5 total points (-110)

Field goals are not likely to get the job done when the NFL's top two offenses go head-to-head in the Motor City on Sunday.

The teams rank first and second in the league in points scored per game, with the Lions on top of the list at 32.1 points per game and the Bills following with 30.5 per contest.

The Lions have failed to reach 20 points only once all season (in their solitary loss to the Tampa Bay Buccaneers in Week 2), while the Bills have scored 30 or more points in each of their last seven games.

That wasn't enough for a win last week, as they lost to the Rams and that was the fourth time in five games that they had allowed 20 or more points, so they could struggle to hold back the rampant Lions offense.

Six of the Bills' last eight games have hit the Over, and the two that hit the Under happened when opponents scored 10 points or less. The Lions can be expected to fare much better than that in a potential shootout.

Khalil Shakir Over 54.5 receiving yards (-110)

The Bills' arsenal of weapons should be improved for this game with wide receiver Keon Coleman and first-choice tight end Dalton Kincaid set to return after missing several games.

However, leading receiver Khalil Shakir should be able to keep up the good work he has done in their absence.

Shakir shined against the Rams with 106 receiving yards and a touchdown and he has been targeted by QB Josh Allen at least seven times in each of his last seven games.

His two best performances of the season have both come on the road as his other 100-yard game came in Seattle in Week 8, and he should test a Lions secondary who allowed the Packers' Christian Watson to post 114 receiving yards last week.

Jahmyr Gibbs longest rush Over 17.5 yards (-125)

Keeping Lions running back Jahmyr Gibbs bottled up has proved beyond the capabilities NFL defenses this season, and the shifty runner can usually be relied upon to pop at least one significant run per game.

Gibbs has had a rush of 18 yards or more in seven of his last eight games, falling just short of his longest rush line for this game against the Colts, when his best effort was 17 yards.

The Bills are a middle-of-the-pack team in terms of defending the rush, giving up 123.1 yards per game on the ground and they could struggle to prevent Gibbs from breaking off another decent gain.

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Buffalo Bills vs. Detroit Lions odds

Buffalo Bills	+125 ML
Detroit Lions	-150 ML
Spread	DET Lions -2.5
Total Points	O/U 54.5

Buffalo Bills vs. Detroit Lions player props

Anytime Touchdown

David Montgomery (DET Lions)	-175
Jahmyr Gibbs (DET Lions)	-150
James Cook (BUF Bills)	-120
Amon-Ra St Brown (DET Lions)	+100
Josh Allen (BUF Bills)	+120
Amari Cooper (BUF Bills)	+150

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This article was written by a partner sports writer via Spotlight Sports Group. All odds displayed on this page were correct at the time of writing and are subject to withdrawal or change at any time.