Michigan State vs. Oregon: Picks, Predictions and Odds

Friday night brings us a Week 6 matchup between Michigan State and No. 6 Oregon and with the two teams coming off very different performances, the odds suggest this game could be a one-sided affair.

The Spartans travel to Autzen Stadium to face the high-powered Ducks, who are vying for a spot in the College Football Playoff.

Let’s break down the betting picks and predictions for this game.

Michigan State vs Oregon betting picks and predictions

Michigan State +24.5 (-115)

Despite Oregon being heavily favored, Michigan State at +24.5 seems like an attractive option.

The Spartans are in a rebuilding phase under coach Jonathan Smith, but he is plenty familiar with Oregon. Smith is an Oregon State alumni and former head coach of the Beavers.

While they’ve had their struggles, they’re showing some fight and Smith will have the Spartans ready to play in this one.

Last weekend, Michigan State was trounced 38-7 by Ohio State, but they managed to keep the game at 10-7 until a late second-quarter collapse.

That was a 31-point defeat and Oregon will likely be aiming for a similar margin to match Ohio State for potential tiebreakers down the road.

Michigan State's defense has shown some signs of resilience, allowing fewer than 24 points in three of their four games against FBS opponents.

However, their offense has struggled, especially with sophomore quarterback Aidan Chiles showing inconsistency. He threw for only 167 yards with a touchdown and an interception against Ohio State and he’s yet to eclipse 200 yards in back-to-back tough games.

The Spartans’ best chance at covering the spread is slowing the game down and keeping Oregon’s offense off the field.

Oregon, led by quarterback Dillon Gabriel and running back Jordan James, has been dominant but hasn’t covered big spreads consistently.

The Ducks failed to cover against Boise State and Idaho and fell short of the 23.5-point spread against UCLA last week, even though they won 34-13.

With a massive showdown against Ohio State looming next week, Oregon might not look to run up the score in this spot, making Michigan State a solid bet to cover +24.5.

Under 52.5 total points (-110)

Looking at Under 52.5 total points for this game seems logical considering Michigan State’s defensive tendencies and Oregon’s efficiency over explosiveness.

The Spartans have yet to play in a game that hit more than 52 total points this season, with their highest-scoring affair being a 27-24 win over Maryland.

Meanwhile, Oregon is averaging 40 points per game, good for 14th in the nation, but has tended to control the clock once they build a lead.

Gabriel has been efficient, completing an eye-popping 81.5 percent of his passes, but the Ducks haven't been overly reliant on explosive plays, with James’ longest rush being just 16 yards.

Oregon’s defense has been solid but not impenetrable, allowing at least 13 points in every game this season.

Michigan State, even with their offensive struggles, should be able to put up at least two scores, especially if they can improve their time of possession through running back KayRon Adams.

However, the Spartans' inability to generate big plays on offense means they’re unlikely to score much beyond that.

One potential risk to the Under is Chiles’ penchant for turnovers. He’s thrown eight interceptions this season, which could set up Oregon with short fields and quick scores.

However, with the Ducks' focus likely on preserving their health for the Ohio State game in Week 7, they might slow the tempo once they’ve built a comfortable lead.

Oregon’s defense will likely hold the Spartans to around 14 points, but I don’t see them scoring enough to push this game over the 52.5-point total.

A final score of 35-14 seems like a realistic outcome, keeping it Under and giving Michigan State the cover.

Read more betting picks and predictions for College Football on site.

Michigan State vs. Oregon odds

Michigan State	+1100 ML
Oregon	-2100 ML
Spread	Oregon -24.5
Total Points	O/U 52.5

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This article was written by a partner sports writer via Spotlight Sports Group. All odds displayed on this page were correct at the time of writing and are subject to withdrawal or change at any time.