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San Francisco Giants vs. Arizona Diamondbacks: Picks, Predictions, Odds and Player Props

The first half of the 2025 MLB season has featured plenty of compelling games, and the action continues on the diamond on Monday with a matchup in the uber-competitive National League West between the San Francisco Giants and Arizona Diamondbacks on Monday.

Both of these teams appeared to be in good shape to make the playoffs in a loaded National League, but each side has fallen on hard times of late. San Francisco has fallen to third place in the NL West after dropping six of the past 10 games. On the other side, the Diamondbacks were just swept by the lowly Miami Marlins, and Arizona now sits five games back in the Wild Card race heading into July. 

Both of these teams could really use a series win to make up ground in the playoff chase, especially with the likes of the San Diego Padres and Los Angeles Dodgers continuing to win games at the top of the division. 

Will the Giants get off on the right foot to start this important series, or will the Diamondbacks bounce back and pick up a much-needed victory in front of their home fans? Let’s get into the odds, plus our expert’s betting picks and predictions for this contest.   

San Francisco Giants vs. Arizona Diamondbacks betting picks and predictions

San Francisco Giants ML (-155)

Even with their recent struggles, the Giants are in the midst of a strong season, and San Francisco has certainly not struggled when Logan Webb has gotten the ball in 2025. 

Webb has long been one of the more underrated pitchers in the game, and the right-hander has been excellent regardless of venue this season, to the tune of a 2.52 ERA and just 30 earned runs allowed over 17 outings. 

What’s more impressive are Webb’s underlying metrics, as he currently sits inside the top 20 percent of all qualified pitchers in xERA, strikeout percentage, walk rate, barrel rate and ground-ball rate. 

With that in mind, our expert sees no reason to expect Webb to suddenly turn in a bad outing on Monday, especially since he’s historically had success against the likes of Ketel Marte, Eugenio Suarez and others in the Arizona lineup. 

On the other side, Ryne Nelson is not nearly the same pitcher as Webb, and even though his last couple of starts have been strong, he still struggled against the Giants earlier this season and that could rear its ugly head once again on Monday.

Ultimately, our expert is backing the Diamondbacks on the money line to take the first game of this series and get back in the National League playoff race. 

Over 8.0 Total Runs (-115)

While Webb being on the mound would usually point our expert in the direction of the under, the Diamondbacks offense has been one of the best units in baseball all season long for a reason. 

Therefore, even though Arizona might not win this game outright, the Diamondbacks still should scratch across at least a couple of runs on Monday. 

While the Giants offense has been inconsistent of late, it’s also worth noting that Nelson’s expected metrics (4.10 xERA, 23.9% chase rate) suggest that he’s due for some regression sooner rather than later. 

Lastly, even if both starters end up performing above expectations in this one, both of these bullpens have struggled recently, which also aids our handicap of the over.  

All things considered, the over 8 total runs is our game totals pick on this NL West matchup on Monday.

Read more betting picks and predictions for MLB on site.

San Francisco Giants vs. Arizona Diamondbacks odds

San Francisco Giants

-155 ML

Arizona Diamondbacks

+130 ML

Run Line

SF Giants -1.5

Total

O/U 8.0

San Francisco Giants vs. Arizona Diamondbacks player props

Player Home Run Odds

Rafael Devers (SF Giants)

+270

Heliot Ramos (SF Giants)

+500

Will Adames (SF Giants)

+550

Eugenio Suarez (ARI Diamondbacks)

+550

Ketel Marte (ARI Diamondbacks)

+600

Pavin Smith (ARI Diamondbacks)

+750

Read the latest MLB news on site.

This article was written by a partner sports writer via Spotlight Sports Group. All odds displayed on this page were correct at the time of writing and are subject to withdrawal or change at any time.

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