San Diego Padres vs. Los Angeles Dodgers: Picks, Predictions, Odds and Player Props

The first couple of months of the 2025 MLB season have featured plenty of compelling contests, and the action continues on the diamond on Monday with a fantastic rivalry matchup between the San Diego Padres and Los Angeles Dodgers.

These teams recently played in San Diego less than a week ago, and it was a series to remember, as the Dodgers took two out of three from the Padres, including a series opener that was very reminiscent of the games they played in the 2024 National League Division Series.

The Padres are coming off a series loss in Arizona, while the Dodgers just went 4-2 against the Padres and San Francisco Giants over the past week. Given how close the NL West is, these games in June could go a long way to deciding the division champion and potential top seed in the National League come playoff time. 

Will the Dodgers keep rolling and maintain their grip on first place in the NL West, or will the Padres get back into the win column with a victory over Los Angeles on the road? Let’s get into the odds, plus our expert’s betting picks and predictions for this contest.

San Diego Padres vs. Los Angeles Dodgers betting picks and predictions

Los Angeles Dodgers ML (-155)

At this point, the Dodgers are a team that has the capacity to lose to inferior opponents, but they clearly take games against divisional rivals and teams near the top of the league more seriously. 

This has certainly been the case this season, as we’ve seen Los Angeles drop series to the likes of the Angels and Nationals, while also besting the Yankees, Padres and Giants in the same breath.   

While the Padres have been a thorn in the side of the Dodgers in recent seasons, our expert is of the opinion that the hosts will get off on the right foot and capture the series opener at Dodger Stadium on Monday. 

After missing over a year due to injury, Shohei Ohtani is finally set to make his return to the mound on Monday at Dodger Stadium. Ohtani might not have the longest leash in this game, but he’s still an excellent pitcher, and he’ll be handing the ball off to an excellent Dodgers bullpen after he exits. 

His opponent on the mound, Dylan Cease, is in the midst of another inconsistent season, and while he did put up his best outing of the campaign against this same Dodgers team a week ago, his expected metrics still suggest that he’s due for a bit of regression, particularly when it comes to allowing hard contact. 

The Dodgers lineup is still the stronger unit in this game, and the pitching matchup could also lean in favor of Los Angeles if Ohtani ends up throwing more than a few innings. 

Ultimately, the Dodgers should be able to take the first game of this series and maintain their lead in the NL West, so our expert will back Los Angeles on the money line. 

Over 9.0 (-105)

While the Dodgers on the money line are our preferred play in this game, our expert is also targeting the Over 9.0 at -105 in this contest. 

Given that this marks the first start for Shohei Ohtani, its reasonable to suggest that the All-World player could be operating with a bit of a short leash on Monday. If the Padres are able to scratch off an early run or two, Dave Roberts could turn to his long relievers, and then all bets are off.

On the other side, the Dodgers offense is an elite unit and should be able to keep on rolling following strong performances on Saturday and Sunday at home. Los Angeles has still averaged nearly six runs per game over its past nine contests, which bodes well for its output in this one.  

All things considered, we can only look at the other over in Monday’s matchup.

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San Diego Padres vs. Los Angeles Dodgers odds

San Diego Padres	+130 ML
Los Angeles Dodgers	-155 ML
Run Line	LAD -1.5 (+130)
Total	O/U 9.0

San Diego Padres vs. Los Angeles Dodgers player props

Player Home Run Odds

Manny Machado (SD Padres)	+350
Fernando Tatis Jr. (SD Padres)	+375
Jake Cronenworth (SD Padres)	+600
Shohei Ohtani (LA Dodgers)	+210
Andy Pages (LA Dodgers)	+450
Mookie Betts (LA Dodgers)	+475

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This article was written by a partner sports writer via Spotlight Sports Group. All odds displayed on this page were correct at the time of writing and are subject to withdrawal or change at any time.