New York Yankees vs. Boston Red Sox: Picks, Predictions, Odds and Player Props

The 2025 MLB season rolls on this weekend with a matchup between a couple of heated rivals in the American League East as the Boston Red Sox get set to host the New York Yankees on Saturday. 

Both of these teams were expected to be playoff-caliber sides prior to the season, and while the Red Sox have disappointed compared to expectations up to this point, these rivalry games rarely disappoint.

Friday’s series opener was a total pitchers’ duel, with the Red Sox notching their third win over the Yankees in just four meetings on the season. Boston is looking to keep the momentum going and win its third consecutive series with a win on Saturday.

On the other side, the Yankees are clearly the top team in the AL East, but New York is in need of a bounce-back performance following a loss in extra innings on Friday. 

Will the Yankees get back into the win column on the road, or will the Red Sox keep things rolling at Fenway Park? Let’s get into the odds, plus our expert’s betting picks and predictions for this contest.   

New York Yankees vs. Boston Red Sox betting picks and predictions

New York Yankees 5 innings line -0.5 (-130)

Our expert was all over Boston on the money line in Friday's contest. However, the Yankees have the decided edge on the mound on Saturday, which is why our expert is going to target the visitors in the first five innings of this matchup. 

The biggest feather in the cap for the Yankees in this game is that they are due for a bit of positive regression on offense following a paltry one-run performance in the series opener. 

Aaron Boone’s team should be in a good position to bounce back on Saturday, especially since they'll be taking on Red Sox starter Hunter Dobbins (4.20 ERA, bottom 20th percentile strikeout rate), who surrendered a couple of homers to Aaron Judge and New York just a week ago. 

As for the Yankees’ own starting pitcher, New York should also get a nice outing from Carlos Rodon, who has allowed just six runs over his past five starts on the road this season. Rodon has been shaky against the Red Sox over the past few seasons, but he has the advantage of having just faced Boston in his last start, which should inform how he plans to attack the Red Sox bats on Saturday. 

Ultimately, our expert will avoid the potential for a bullpen collapse and target New York in the first five innings on the run line. 

Over 8.5 (-105)

While our expert likes New York as the side in this game, this pitching matchup is one that immediately points us in the direction of the over, especially since both lineups were cold on Friday. 

After all, these are two of the best lineups in the game, featuring a number of hitters that have the ability to break the game open with one swing.

Furthermore, it’s not as if both pitchers have been infallible this season, including just last week, when the starters combined to allow eight runs in an 11-7 Boston win.

Additionally, both bullpens have been inconsistent of late, including in last week’s series, which saw a trio of high-scoring games. 

At the end of the day, our expert can only look toward over 8.5 at -105 on Saturday.

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New York Yankees vs. Boston Red Sox odds

New York Yankees	-165
Boston Red Sox	+140
Run Line	NY Yankees -1.5
Total	O/U 8.5

New York Yankees vs. Boston Red Sox player props

Player Home Run Odds

Aaron Judge (NY Yankees)	+275
Ben Rice (NY Yankees)	+550
Jazz Chisholm (NY Yankees)	+750
Rafael Devers (BOS Red Sox)	+525
Romy Gonzalez (BOS Red Sox)	+700
Rob Refsnyder (BOS Red Sox)	+750

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This article was written by a partner sports writer via Spotlight Sports Group. All odds displayed on this page were correct at the time of writing and are subject to withdrawal or change at any time.